Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis

Torben Lykke Sørensen; F Sellebjerg

Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis

Institut for Klinisk Medicin

27 Citationer (Scopus)

Abstract

We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.

Originalsprog	Engelsk
Tidsskrift	Multiple Sclerosis
Vol/bind	8
Udgave nummer	2
Sider (fra-til)	104-7
Antal sider	4
ISSN	1352-4585
Status	Udgivet - apr. 2002

Citationsformater

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title = "Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis",

abstract = "We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.",

keywords = "Adult, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Disability Evaluation, Down-Regulation, Female, Humans, Immunologic Factors, Interferon-beta, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Receptors, CXCR3, Receptors, Chemokine, T-Lymphocyte Subsets, Time Factors",

author = "S{\o}rensen, {Torben Lykke} and F Sellebjerg",

year = "2002",

month = apr,

language = "English",

volume = "8",

pages = "104--7",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications",

number = "2",

}

TY - JOUR

T1 - Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis

AU - Sørensen, Torben Lykke

AU - Sellebjerg, F

PY - 2002/4

Y1 - 2002/4

N2 - We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.

AB - We studied the expression of chemokine receptors CCR1, CCR2, CCR3, CCR5, and CXCR3 on CD4 and CD8 positive T cells, and on CD14 positive monocytes in blood from 10 patients with relapsing-remitting multiple sclerosis (MS) at initiation of interferon (IFN)-beta treatment, after 1 month and after 3 months of treatment. It was found that the expression of CXCR3 on CD4+ and CD8+ T cells was significantly reduced after 3 months of treatment. The expression of other receptors was unaltered. Since CXCR3 cells are enriched in cerebrospinal fluid (CSF), and are detected in lesion material in MS this may represent an important mode of action of interferon-beta in MS.

KW - Adult

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Disability Evaluation

KW - Down-Regulation

KW - Female

KW - Humans

KW - Immunologic Factors

KW - Interferon-beta

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Receptors, CXCR3

KW - Receptors, Chemokine

KW - T-Lymphocyte Subsets

KW - Time Factors

M3 - Journal article

C2 - 11990865

SN - 1352-4585

VL - 8

SP - 104

EP - 107

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 2

ER -

Selective suppression of chemokine receptor CXCR3 expression by interferon-beta1a in multiple sclerosis

Abstract

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Citationsformater