Seasonal changes in human immune responses to malaria

TY - JOUR

T1 - Seasonal changes in human immune responses to malaria

AU - Hviid, L

AU - Theander, T G

PY - 1993

Y1 - 1993

N2 - Cellular as well as humorol immune responses to malaria antigens fluctuate in time in individuals living in molono-endemic areas, particularly where malaria transmission is seasonal. The most pronounced changes are seen in association with clinical attacks, but osymptomatic infection can also lead to apparent immune depression. However, recent data have shown that seasonal variation in cellular immune responses may occur even in the absence of detectable porositaemia. Here, Lars Hviid and Thor G. Theonder review the seasonal variation in human immune responses to malaria, and discuss its possible causes and implications.

AB - Cellular as well as humorol immune responses to malaria antigens fluctuate in time in individuals living in molono-endemic areas, particularly where malaria transmission is seasonal. The most pronounced changes are seen in association with clinical attacks, but osymptomatic infection can also lead to apparent immune depression. However, recent data have shown that seasonal variation in cellular immune responses may occur even in the absence of detectable porositaemia. Here, Lars Hviid and Thor G. Theonder review the seasonal variation in human immune responses to malaria, and discuss its possible causes and implications.

U2 - 10.1016/0169-4758%2893%2990160-H

DO - 10.1016/0169-4758%2893%2990160-H

M3 - Journal article

C2 - 15463661

SN - 1471-4922

VL - 9

SP - 26

EP - 27

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 1

ER -