Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study

Kamlesh Khunti; Nick Taub; Jennifer Tringham; Janet Jarvis; Azhar Farooqi; T. Chas Skinner; Melanie J. Davies

doi:10.1016/j.pcd.2010.01.002

Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study

Kamlesh Khunti^*, Nick Taub, Jennifer Tringham, Janet Jarvis, Azhar Farooqi, T. Chas Skinner, Melanie J. Davies

^*Corresponding author af dette arbejde

Inflammation, Metabolism and Oxidation

22 Citationer (Scopus)

Abstract

Aims: To estimate the prevalence of metabolic syndrome in a general population sample of south Asians and white Europeans and compare predictors of metabolic syndrome, using ethnic specific definitions of obesity. Methods: 3099 participants (71.4% white European, 28.6% south Asian) aged 40-75 years were screened using a 75 g oral glucose tolerance test. Metabolic syndrome was defined using National Cholesterol Education Programme and International Diabetes Federation definitions. We compared sensitivity, specificity and area under the curve of waist circumference, body mass index and waist-hip ratio. Results: The prevalence of metabolic syndrome using the definitions above was 29.9% (29.2% south Asian, 30.2% white European), and 34.4% (34.2% south Asian, 34.5% white European), respectively. Using the National Cholesterol Education Programme definition, waist circumference was significantly more predictive of metabolic syndrome than body mass index or waist-hip ratio. The area under the curve for waist circumference was 0.75 (95% CI: 0.69-0.80) and 0.76 (0.72-0.81) for south Asian men and women; 0.83 (0.80-0.85) and 0.80 (0.77-0.82) for white European men and women. Conclusions: The prevalence of metabolic syndrome is high in both south Asian and white European populations. Waist circumference is a simple and effective measure for predicting metabolic syndrome in different populations.

Originalsprog	Engelsk
Tidsskrift	Primary Care Diabetes
Vol/bind	4
Udgave nummer	1
Sider (fra-til)	25-32
Antal sider	8
ISSN	1751-9918
DOI	https://doi.org/10.1016/j.pcd.2010.01.002
Status	Udgivet - 1 apr. 2010

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10.1016/j.pcd.2010.01.002

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Citationsformater

Khunti, K., Taub, N., Tringham, J., Jarvis, J., Farooqi, A., Skinner, T. C., & Davies, M. J. (2010). Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study. Primary Care Diabetes, 4(1), 25-32. https://doi.org/10.1016/j.pcd.2010.01.002

Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans : A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study. / Khunti, Kamlesh; Taub, Nick; Tringham, Jennifer et al.

I: Primary Care Diabetes, Bind 4, Nr. 1, 01.04.2010, s. 25-32.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Khunti, K, Taub, N, Tringham, J, Jarvis, J, Farooqi, A, Skinner, TC & Davies, MJ 2010, 'Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study', Primary Care Diabetes, bind 4, nr. 1, s. 25-32. https://doi.org/10.1016/j.pcd.2010.01.002

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title = "Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study",

abstract = "Aims: To estimate the prevalence of metabolic syndrome in a general population sample of south Asians and white Europeans and compare predictors of metabolic syndrome, using ethnic specific definitions of obesity. Methods: 3099 participants (71.4% white European, 28.6% south Asian) aged 40-75 years were screened using a 75 g oral glucose tolerance test. Metabolic syndrome was defined using National Cholesterol Education Programme and International Diabetes Federation definitions. We compared sensitivity, specificity and area under the curve of waist circumference, body mass index and waist-hip ratio. Results: The prevalence of metabolic syndrome using the definitions above was 29.9% (29.2% south Asian, 30.2% white European), and 34.4% (34.2% south Asian, 34.5% white European), respectively. Using the National Cholesterol Education Programme definition, waist circumference was significantly more predictive of metabolic syndrome than body mass index or waist-hip ratio. The area under the curve for waist circumference was 0.75 (95% CI: 0.69-0.80) and 0.76 (0.72-0.81) for south Asian men and women; 0.83 (0.80-0.85) and 0.80 (0.77-0.82) for white European men and women. Conclusions: The prevalence of metabolic syndrome is high in both south Asian and white European populations. Waist circumference is a simple and effective measure for predicting metabolic syndrome in different populations.",

keywords = "Anthropometry, Ethnicity, Metabolic syndrome, Screening, Waist circumference",

author = "Kamlesh Khunti and Nick Taub and Jennifer Tringham and Janet Jarvis and Azhar Farooqi and Skinner, {T. Chas} and Davies, {Melanie J.}",

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AU - Khunti, Kamlesh

AU - Taub, Nick

AU - Tringham, Jennifer

AU - Jarvis, Janet

AU - Farooqi, Azhar

AU - Skinner, T. Chas

AU - Davies, Melanie J.

PY - 2010/4/1

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N2 - Aims: To estimate the prevalence of metabolic syndrome in a general population sample of south Asians and white Europeans and compare predictors of metabolic syndrome, using ethnic specific definitions of obesity. Methods: 3099 participants (71.4% white European, 28.6% south Asian) aged 40-75 years were screened using a 75 g oral glucose tolerance test. Metabolic syndrome was defined using National Cholesterol Education Programme and International Diabetes Federation definitions. We compared sensitivity, specificity and area under the curve of waist circumference, body mass index and waist-hip ratio. Results: The prevalence of metabolic syndrome using the definitions above was 29.9% (29.2% south Asian, 30.2% white European), and 34.4% (34.2% south Asian, 34.5% white European), respectively. Using the National Cholesterol Education Programme definition, waist circumference was significantly more predictive of metabolic syndrome than body mass index or waist-hip ratio. The area under the curve for waist circumference was 0.75 (95% CI: 0.69-0.80) and 0.76 (0.72-0.81) for south Asian men and women; 0.83 (0.80-0.85) and 0.80 (0.77-0.82) for white European men and women. Conclusions: The prevalence of metabolic syndrome is high in both south Asian and white European populations. Waist circumference is a simple and effective measure for predicting metabolic syndrome in different populations.

AB - Aims: To estimate the prevalence of metabolic syndrome in a general population sample of south Asians and white Europeans and compare predictors of metabolic syndrome, using ethnic specific definitions of obesity. Methods: 3099 participants (71.4% white European, 28.6% south Asian) aged 40-75 years were screened using a 75 g oral glucose tolerance test. Metabolic syndrome was defined using National Cholesterol Education Programme and International Diabetes Federation definitions. We compared sensitivity, specificity and area under the curve of waist circumference, body mass index and waist-hip ratio. Results: The prevalence of metabolic syndrome using the definitions above was 29.9% (29.2% south Asian, 30.2% white European), and 34.4% (34.2% south Asian, 34.5% white European), respectively. Using the National Cholesterol Education Programme definition, waist circumference was significantly more predictive of metabolic syndrome than body mass index or waist-hip ratio. The area under the curve for waist circumference was 0.75 (95% CI: 0.69-0.80) and 0.76 (0.72-0.81) for south Asian men and women; 0.83 (0.80-0.85) and 0.80 (0.77-0.82) for white European men and women. Conclusions: The prevalence of metabolic syndrome is high in both south Asian and white European populations. Waist circumference is a simple and effective measure for predicting metabolic syndrome in different populations.

KW - Anthropometry

KW - Ethnicity

KW - Metabolic syndrome

KW - Screening

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