Screening for fetal trisomy 21 in gestational weeks 6 and 7

Helen N. Madsen; Olav B. Petersen; Niels Tørring

doi:10.3109/00016349.2010.489600

Screening for fetal trisomy 21 in gestational weeks 6 and 7

Helen N. Madsen, Olav B. Petersen, Niels Tørring

3 Citationer (Scopus)

Abstract

The objective was to examine the applicability of the two biochemical markers PAPP-A and free β-hCG for fetal trisomy 21 (T21) in very early pregnancy: gestational weeks (GA) 6 and 7. Medians for the two markers were generated on 36,745 fetal T21 unaffected pregnancies from gestational weeks 614. Concentrations were converted to Multiples of the Medians (MoMs). Median MoM from T21 affected pregnancies were compared over three intervals of gestational age; the very early weeks 6 and 7, weeks 810 and weeks 1114. Median MoM from 9 affected pregnancies with a very early blood sample had a PAPP-A median MoM of 0.269, compared to 0.392 in weeks 810 and 0.531 in weeks 1114. On the contrary, free β-hCG diverged from the median with increasing gestational age. Our data suggest that PAPP-A is a useful marker for very early testing in first trimester screening for fetal T21.

Originalsprog	Engelsk
Tidsskrift	Acta Obstetricia et Gynecologica Scandinavica
Vol/bind	89
Udgave nummer	9
Sider (fra-til)	1218-1221
ISSN	0001-6349
DOI	https://doi.org/10.3109/00016349.2010.489600
Status	Udgivet - 2010
Udgivet eksternt	Ja

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10.3109/00016349.2010.489600

https://onlinelibrary.wiley.com/doi/pdfdirect/10.3109/00016349.2010.489600

Citationsformater

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title = "Screening for fetal trisomy 21 in gestational weeks 6 and 7",

abstract = "The objective was to examine the applicability of the two biochemical markers PAPP-A and free β-hCG for fetal trisomy 21 (T21) in very early pregnancy: gestational weeks (GA) 6 and 7. Medians for the two markers were generated on 36,745 fetal T21 unaffected pregnancies from gestational weeks 614. Concentrations were converted to Multiples of the Medians (MoMs). Median MoM from T21 affected pregnancies were compared over three intervals of gestational age; the very early weeks 6 and 7, weeks 810 and weeks 1114. Median MoM from 9 affected pregnancies with a very early blood sample had a PAPP-A median MoM of 0.269, compared to 0.392 in weeks 810 and 0.531 in weeks 1114. On the contrary, free β-hCG diverged from the median with increasing gestational age. Our data suggest that PAPP-A is a useful marker for very early testing in first trimester screening for fetal T21.",

keywords = "Down's syndrome, First trimester, Free β-hCG, PAPP-A, Trisomy 21",

author = "Madsen, {Helen N.} and Petersen, {Olav B.} and Niels T{\o}rring",

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doi = "10.3109/00016349.2010.489600",

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AU - Madsen, Helen N.

AU - Petersen, Olav B.

AU - Tørring, Niels

PY - 2010

Y1 - 2010

N2 - The objective was to examine the applicability of the two biochemical markers PAPP-A and free β-hCG for fetal trisomy 21 (T21) in very early pregnancy: gestational weeks (GA) 6 and 7. Medians for the two markers were generated on 36,745 fetal T21 unaffected pregnancies from gestational weeks 614. Concentrations were converted to Multiples of the Medians (MoMs). Median MoM from T21 affected pregnancies were compared over three intervals of gestational age; the very early weeks 6 and 7, weeks 810 and weeks 1114. Median MoM from 9 affected pregnancies with a very early blood sample had a PAPP-A median MoM of 0.269, compared to 0.392 in weeks 810 and 0.531 in weeks 1114. On the contrary, free β-hCG diverged from the median with increasing gestational age. Our data suggest that PAPP-A is a useful marker for very early testing in first trimester screening for fetal T21.

AB - The objective was to examine the applicability of the two biochemical markers PAPP-A and free β-hCG for fetal trisomy 21 (T21) in very early pregnancy: gestational weeks (GA) 6 and 7. Medians for the two markers were generated on 36,745 fetal T21 unaffected pregnancies from gestational weeks 614. Concentrations were converted to Multiples of the Medians (MoMs). Median MoM from T21 affected pregnancies were compared over three intervals of gestational age; the very early weeks 6 and 7, weeks 810 and weeks 1114. Median MoM from 9 affected pregnancies with a very early blood sample had a PAPP-A median MoM of 0.269, compared to 0.392 in weeks 810 and 0.531 in weeks 1114. On the contrary, free β-hCG diverged from the median with increasing gestational age. Our data suggest that PAPP-A is a useful marker for very early testing in first trimester screening for fetal T21.

KW - Down's syndrome

KW - First trimester

KW - Free β-hCG

KW - PAPP-A

KW - Trisomy 21

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DO - 10.3109/00016349.2010.489600

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JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

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ER -

Screening for fetal trisomy 21 in gestational weeks 6 and 7

Abstract

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