Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load

Per Kallestrup; Rutendo Zinyama; Exnevia Gomo; Anthony E Butterworth; Boniface Mudenge; Govert J van Dam; Jan Gerstoft; Christian Erikstrup; Henrik Ullum

doi:10.1086/497696

Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load

Per Kallestrup, Rutendo Zinyama, Exnevia Gomo, Anthony E Butterworth, Boniface Mudenge, Govert J van Dam, Jan Gerstoft, Christian Erikstrup, Henrik Ullum

95 Citationer (Scopus)

Abstract

To determine whether treatment of schistosomiasis has an effect on the course of human immunodeficiency virus type 1 (HIV-1) infection, individuals with schistosomiasis and with or without HIV-1 infection were randomized to receive praziquantel treatment at inclusion or after a delay of 3 months; 287 participants were included in the study, and 227 (79%) were followed up. Among the 130 participants who were coinfected, those who received early treatment (n=64) had a significantly lower increase in plasma HIV-1 RNA load than did those who received delayed treatment (n=66) (P

Originalsprog	Engelsk
Tidsskrift	Journal of Infectious Diseases
Vol/bind	192
Udgave nummer	11
Sider (fra-til)	1956-61
Antal sider	6
ISSN	0022-1899
DOI	https://doi.org/10.1086/497696
Status	Udgivet - 2005

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10.1086/497696

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title = "Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load",

abstract = "To determine whether treatment of schistosomiasis has an effect on the course of human immunodeficiency virus type 1 (HIV-1) infection, individuals with schistosomiasis and with or without HIV-1 infection were randomized to receive praziquantel treatment at inclusion or after a delay of 3 months; 287 participants were included in the study, and 227 (79%) were followed up. Among the 130 participants who were coinfected, those who received early treatment (n=64) had a significantly lower increase in plasma HIV-1 RNA load than did those who received delayed treatment (n=66) (P",

keywords = "Adult, Anthelmintics, CD4 Lymphocyte Count, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Male, Praziquantel, RNA, Viral, Rural Population, Schistosomiasis, Treatment Outcome, Viral Load, Zimbabwe",

author = "Per Kallestrup and Rutendo Zinyama and Exnevia Gomo and Butterworth, {Anthony E} and Boniface Mudenge and {van Dam}, {Govert J} and Jan Gerstoft and Christian Erikstrup and Henrik Ullum",

year = "2005",

doi = "10.1086/497696",

language = "English",

volume = "192",

pages = "1956--61",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

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T1 - Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load

AU - Kallestrup, Per

AU - Zinyama, Rutendo

AU - Gomo, Exnevia

AU - Butterworth, Anthony E

AU - Mudenge, Boniface

AU - van Dam, Govert J

AU - Gerstoft, Jan

AU - Erikstrup, Christian

AU - Ullum, Henrik

PY - 2005

Y1 - 2005

N2 - To determine whether treatment of schistosomiasis has an effect on the course of human immunodeficiency virus type 1 (HIV-1) infection, individuals with schistosomiasis and with or without HIV-1 infection were randomized to receive praziquantel treatment at inclusion or after a delay of 3 months; 287 participants were included in the study, and 227 (79%) were followed up. Among the 130 participants who were coinfected, those who received early treatment (n=64) had a significantly lower increase in plasma HIV-1 RNA load than did those who received delayed treatment (n=66) (P

AB - To determine whether treatment of schistosomiasis has an effect on the course of human immunodeficiency virus type 1 (HIV-1) infection, individuals with schistosomiasis and with or without HIV-1 infection were randomized to receive praziquantel treatment at inclusion or after a delay of 3 months; 287 participants were included in the study, and 227 (79%) were followed up. Among the 130 participants who were coinfected, those who received early treatment (n=64) had a significantly lower increase in plasma HIV-1 RNA load than did those who received delayed treatment (n=66) (P

KW - Adult

KW - Anthelmintics

KW - CD4 Lymphocyte Count

KW - Drug Administration Schedule

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Praziquantel

KW - RNA, Viral

KW - Rural Population

KW - Schistosomiasis

KW - Treatment Outcome

KW - Viral Load

KW - Zimbabwe

U2 - 10.1086/497696

DO - 10.1086/497696

M3 - Journal article

C2 - 16267767

SN - 0022-1899

VL - 192

SP - 1956

EP - 1961

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 11

ER -

Schistosomiasis and HIV-1 infection in rural Zimbabwe: effect of treatment of schistosomiasis on CD4 cell count and plasma HIV-1 RNA load

Abstract

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