Abstract
The majority of hereditary cancers demonstrate extended variation of phenotype, not only between families, but also within a particular family, who supposedly have inherited the same pathogenic mutation. The present paper reviews genotype-phenotype correlations with examples mainly from the two largest hereditary cancer groups, namely hereditary colorectal cancer and hereditary breast (and ovarian) cancer. It is concluded that knowledge about genotype-phenotype correlations is essential in the cancer genetic clinic; otherwise, the patient tends to base decisions on personal experience, not realising that the course of disease might be different in other family members.
Udgivelsesdato: 2006-Jun-12
Udgivelsesdato: 2006-Jun-12
| Bidragets oversatte titel | Correlations between the patient's genotype and the course of the disease in hereditary cancer diseases |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for læger |
| Vol/bind | 168 |
| Udgave nummer | 24 |
| Sider (fra-til) | 2341-4 |
| Antal sider | 3 |
| ISSN | 0041-5782 |
| Status | Udgivet - 2006 |