Safety considerations for transplanting cryopreserved ovarian tissue to restore fertility in female patients who have recovered from Ewing's sarcoma

TY - JOUR

T1 - Safety considerations for transplanting cryopreserved ovarian tissue to restore fertility in female patients who have recovered from Ewing's sarcoma

AU - Sørensen, Stine D

AU - Greve, Tine

AU - Wielenga, Vera Timmermans

AU - Wallace, W Hamish B

AU - Andersen, Claus Yding

PY - 2014/2

Y1 - 2014/2

N2 - Ewing's sarcoma (EWS) is a highly malignant cancer in children, adolescents and young adults. The chemotherapy required to treat female EWS patients may cause primary ovarian insufficiency and infertility as a side effect. Cryopreservation of ovarian tissue before the start of chemotherapy can potentially preserve fertility. When the patient has been cured and primary ovarian insufficiency has developed, transplantation of frozen/thawed ovarian tissue can restore ovarian function. The tissue is usually collected before chemotherapy is initiated, and malignant cells may contaminate the stored ovarian tissue, potentially causing recrudescence of the original cancer after transplantation. The risk of EWS metastasizing to the ovary is probably low but has not been studied in great detail. This review describes the available evidence on the risk of malignant cell contamination in the ovaries of EWS patients and presents a new case of malignant cells in an ovarian biopsy from a girl with EWS.

AB - Ewing's sarcoma (EWS) is a highly malignant cancer in children, adolescents and young adults. The chemotherapy required to treat female EWS patients may cause primary ovarian insufficiency and infertility as a side effect. Cryopreservation of ovarian tissue before the start of chemotherapy can potentially preserve fertility. When the patient has been cured and primary ovarian insufficiency has developed, transplantation of frozen/thawed ovarian tissue can restore ovarian function. The tissue is usually collected before chemotherapy is initiated, and malignant cells may contaminate the stored ovarian tissue, potentially causing recrudescence of the original cancer after transplantation. The risk of EWS metastasizing to the ovary is probably low but has not been studied in great detail. This review describes the available evidence on the risk of malignant cell contamination in the ovaries of EWS patients and presents a new case of malignant cells in an ovarian biopsy from a girl with EWS.

KW - Antineoplastic Agents

KW - Cryopreservation

KW - Female

KW - Humans

KW - Infertility, Female

KW - Neoplasm Recurrence, Local

KW - Neoplasm Seeding

KW - Ovarian Neoplasms

KW - Ovary

KW - Radiotherapy

KW - Risk

KW - Sarcoma, Ewing

U2 - 10.2217/fon.13.183

DO - 10.2217/fon.13.183

M3 - Journal article

C2 - 24490613

SN - 1479-6694

VL - 10

SP - 277

EP - 283

JO - Future Oncology

JF - Future Oncology

IS - 2

ER -