Rumination-focused cognitive behaviour therapy vs. cognitive behaviour therapy for depression: Study protocol for a randomised controlled superiority trial

Morten Hvenegaard, Ed R Watkins, Stig Poulsen, Nicole K Rosenberg, Matthias Gondan, Ben Grafton, Stephen F Austin, Henriette Howard, Stine B Moeller

    9 Citationer (Scopus)
    1333 Downloads (Pure)

    Abstract

    Background: Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual symptoms by the end of treatment. A common residual symptom is rumination, a process of recurrent negative thinking and dwelling on negative affect. Rumination has been demonstrated as a major factor in vulnerability to depression, predicting the onset, severity, and duration of future depression. Rumination-focused cognitive behavioural therapy is a psychotherapeutic treatment targeting rumination. Because rumination plays a major role in the initiation and maintenance of depression, targeting rumination with rumination-focused cognitive behavioural therapy may be more effective in treating depression and reducing relapse than standard cognitive behavioural therapy. Method/design: This study is a two-arm pragmatic randomised controlled superiority trial comparing the effectiveness of group-based rumination-focused cognitive behaviour therapy with the effectiveness of group-based cognitive behavioural therapy for treatment of depression. One hundred twenty-eight patients with depression will be recruited from and given treatment in an outpatient service at a psychiatric hospital in Denmark. Our primary outcome will be severity of depressive symptoms (Hamilton Rating Scale for Depression) at completion of treatment. Secondary outcomes will be level of rumination, worry, anxiety, quality of life, behavioural activation, experimental measures of cognitive flexibility, and emotional attentional bias. A 6-month follow-up is planned and will include the primary outcome measure and assessment of relapse. Discussion: The clinical outcome of this trial may guide clinicians to decide on the merits of including rumination-focused cognitive behavioural therapy in the treatment of depression in outpatient services.

    OriginalsprogEngelsk
    Artikelnummer344
    TidsskriftTrials
    Vol/bind16
    Udgave nummer1
    Sider (fra-til)1-6
    Antal sider6
    ISSN1745-6215
    DOI
    StatusUdgivet - 11 aug. 2015

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    • ABCT 2015

      Pedersen, M. H. (Taler)

      12 nov. 201515 dec. 2015

      Aktivitet: Deltagelse i eller arrangement af en begivenhed - typerDeltagelse i workshop, seminar og kursus

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