Role of KATP channels in the regulation of rat dura and pia artery diameter

A. Gozalov; K.A. Petersen; C. Mortensen; I. Jansen-Olesen; Dan Arne Klærke; J. Olesen

doi:10.1111/j.1468-2982.2004.00848.x

Role of KATP channels in the regulation of rat dura and pia artery diameter

A. Gozalov, K.A. Petersen, C. Mortensen, I. Jansen-Olesen, Dan Arne Klærke, J. Olesen

14 Citationer (Scopus)

Abstract

The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	25
Udgave nummer	4
Sider (fra-til)	249-260
Antal sider	12
ISSN	0333-1024
DOI	https://doi.org/10.1111/j.1468-2982.2004.00848.x
Status	Udgivet - 2005

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10.1111/j.1468-2982.2004.00848.x

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title = "Role of KATP channels in the regulation of rat dura and pia artery diameter",

abstract = "The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.",

keywords = "Former LIFE faculty, Dural and pial arteries, glibenclamide, KATP channels, levcromakalim, pinacidil",

author = "A. Gozalov and K.A. Petersen and C. Mortensen and I. Jansen-Olesen and Kl{\ae}rke, {Dan Arne} and J. Olesen",

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TY - JOUR

T1 - Role of KATP channels in the regulation of rat dura and pia artery diameter

AU - Gozalov, A.

AU - Petersen, K.A.

AU - Mortensen, C.

AU - Jansen-Olesen, I.

AU - Klærke, Dan Arne

AU - Olesen, J.

PY - 2005

Y1 - 2005

N2 - The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.

AB - The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.

KW - Former LIFE faculty

KW - Dural and pial arteries

KW - glibenclamide

KW - KATP channels

KW - levcromakalim

KW - pinacidil

U2 - 10.1111/j.1468-2982.2004.00848.x

DO - 10.1111/j.1468-2982.2004.00848.x

M3 - Journal article

C2 - 15773822

SN - 0800-1952

VL - 25

SP - 249

EP - 260

JO - Cephalalgia, Supplement

JF - Cephalalgia, Supplement

IS - 4

ER -

Role of KATP channels in the regulation of rat dura and pia artery diameter

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