TY - JOUR
T1 - Role of amino-acid PET in high-grade gliomas
T2 - limitations and perspectives
AU - Verger, Antoine
AU - Arbizu, Javier
AU - Law, Ian
PY - 2018/9
Y1 - 2018/9
N2 - Positron emission tomography (PET) using radiolabeled amino-acids was recently recommended by the Response Assessment in Neuro-Oncology (RANO) working group as an additional tool in the diagnostic assessment of brain tumors. The aim of this review is to summarize available literature data on the role of amino-acid PET imaging in high-grade gliomas (HGGs), with regard to diagnosis, treatment planning and follow-up of these tumors. Indeed, amino-acid PET applications are multiple throughout the evolution of HGGs. However, certain limitations such as lack of specificity, uncertain value for grading and prognostication or the limited data for treatment monitoring should to be taken into account, the latter of which are further developed in this review. Notwithstanding these limitations, amino-acid PET is becoming increasingly accessible in many nuclear medicine centers. Larger prospective cohort prospective studies are thus needed in order to increase the clinical value of this modality and enable its extended use to the largest number of patients.
AB - Positron emission tomography (PET) using radiolabeled amino-acids was recently recommended by the Response Assessment in Neuro-Oncology (RANO) working group as an additional tool in the diagnostic assessment of brain tumors. The aim of this review is to summarize available literature data on the role of amino-acid PET imaging in high-grade gliomas (HGGs), with regard to diagnosis, treatment planning and follow-up of these tumors. Indeed, amino-acid PET applications are multiple throughout the evolution of HGGs. However, certain limitations such as lack of specificity, uncertain value for grading and prognostication or the limited data for treatment monitoring should to be taken into account, the latter of which are further developed in this review. Notwithstanding these limitations, amino-acid PET is becoming increasingly accessible in many nuclear medicine centers. Larger prospective cohort prospective studies are thus needed in order to increase the clinical value of this modality and enable its extended use to the largest number of patients.
KW - Amino Acids/metabolism
KW - Glioma/diagnostic imaging
KW - Humans
KW - Neoplasm Grading
KW - Positron-Emission Tomography/methods
KW - Prognosis
KW - Recurrence
U2 - 10.23736/S1824-4785.18.03092-3
DO - 10.23736/S1824-4785.18.03092-3
M3 - Review
C2 - 29696948
SN - 1824-4785
VL - 62
SP - 254
EP - 266
JO - The Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - The Quarterly Journal of Nuclear Medicine and Molecular Imaging
IS - 3
ER -