Roadmap for a precision-medicine initiative in the Nordic region

Pål Rasmus Njølstad; Ole Andreas Andreassen; Søren Brunak; Anders D Børglum; Joakim Dillner; Tõnu Esko; Paul W Franks; Nelson Freimer; Leif Groop; Hakon Heimer; David M Hougaard; Eivind Hovig; Kristian Hveem; Anu Jalanko; Jaakko Kaprio; Gun Peggy Knudsen; Mads Melbye; Andres Metspalu; Preben Bo Mortensen; Juni Palmgren; Aarno Palotie; Wenche Reed; Hreinn Stefánsson; Nathan O Stitziel; Patrick F Sullivan; Unnur Thorsteinsdóttir; Marc Vaudel; Eero Vuorio; Thomas Werge; Camilla Stoltenberg; Kári Stefánsson

doi:10.1038/s41588-019-0391-1

Roadmap for a precision-medicine initiative in the Nordic region

Pål Rasmus Njølstad, Ole Andreas Andreassen, Søren Brunak, Anders D Børglum, Joakim Dillner, Tõnu Esko, Paul W Franks, Nelson Freimer, Leif Groop, Hakon Heimer, David M Hougaard, Eivind Hovig, Kristian Hveem, Anu Jalanko, Jaakko Kaprio, Gun Peggy Knudsen, Mads Melbye, Andres Metspalu, Preben Bo Mortensen, Juni PalmgrenAarno Palotie, Wenche Reed, Hreinn Stefánsson, Nathan O Stitziel, Patrick F Sullivan, Unnur Thorsteinsdóttir, Marc Vaudel, Eero Vuorio, Thomas Werge, Camilla Stoltenberg, Kári Stefánsson

7 Citationer (Scopus)

Abstract

The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	51
Sider (fra-til)	924-930
ISSN	1061-4036
DOI	https://doi.org/10.1038/s41588-019-0391-1
Status	Udgivet - 1 jun. 2019

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10.1038/s41588-019-0391-1

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Njølstad, P. R., Andreassen, O. A., Brunak, S., Børglum, A. D., Dillner, J., Esko, T., Franks, P. W., Freimer, N., Groop, L., Heimer, H., Hougaard, D. M., Hovig, E., Hveem, K., Jalanko, A., Kaprio, J., Knudsen, G. P., Melbye, M., Metspalu, A., Mortensen, P. B., ... Stefánsson, K. (2019). Roadmap for a precision-medicine initiative in the Nordic region. Nature Genetics, 51, 924-930. https://doi.org/10.1038/s41588-019-0391-1

Njølstad, PR, Andreassen, OA, Brunak, S, Børglum, AD, Dillner, J, Esko, T, Franks, PW, Freimer, N, Groop, L, Heimer, H, Hougaard, DM, Hovig, E, Hveem, K, Jalanko, A, Kaprio, J, Knudsen, GP, Melbye, M, Metspalu, A, Mortensen, PB, Palmgren, J, Palotie, A, Reed, W, Stefánsson, H, Stitziel, NO, Sullivan, PF, Thorsteinsdóttir, U, Vaudel, M, Vuorio, E, Werge, T, Stoltenberg, C & Stefánsson, K 2019, 'Roadmap for a precision-medicine initiative in the Nordic region', Nature Genetics, bind 51, s. 924-930. https://doi.org/10.1038/s41588-019-0391-1

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abstract = "The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.",

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AU - Njølstad, Pål Rasmus

AU - Andreassen, Ole Andreas

AU - Brunak, Søren

AU - Børglum, Anders D

AU - Dillner, Joakim

AU - Esko, Tõnu

AU - Franks, Paul W

AU - Freimer, Nelson

AU - Groop, Leif

AU - Heimer, Hakon

AU - Hougaard, David M

AU - Hovig, Eivind

AU - Hveem, Kristian

AU - Jalanko, Anu

AU - Kaprio, Jaakko

AU - Knudsen, Gun Peggy

AU - Melbye, Mads

AU - Metspalu, Andres

AU - Mortensen, Preben Bo

AU - Palmgren, Juni

AU - Palotie, Aarno

AU - Reed, Wenche

AU - Stefánsson, Hreinn

AU - Stitziel, Nathan O

AU - Sullivan, Patrick F

AU - Thorsteinsdóttir, Unnur

AU - Vaudel, Marc

AU - Vuorio, Eero

AU - Werge, Thomas

AU - Stoltenberg, Camilla

AU - Stefánsson, Kári

PY - 2019/6/1

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AB - The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

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Roadmap for a precision-medicine initiative in the Nordic region

Abstract

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