RNAcentral: a hub of information for non-coding RNA sequences

Jan Gorodkin, Ernst Stefan Seemann, The RNAcentral Constortium

    50 Citationer (Scopus)
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    Abstract

    RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences of all types from a broad range of organisms. We have recently added a new genome mapping pipeline that identifies genomic locations for ncRNA sequences in 296 species. We have also added several new types of functional annotations, such as tRNA secondary structures, Gene Ontology annotations, and miRNA-target interactions. A new quality control mechanism based on Rfam family assignments identifies potential contamination, incomplete sequences, and more. The RNAcentral database has become a vital component of many workflows in the RNA community, serving as both the primary source of sequence data for academic and commercial groups, as well as a source of stable accessions for the annotation of genomic and functional features. These examples are facilitated by an improved RNAcentral web interface, which features an updated genome browser, a new sequence feature viewer, and improved text search functionality. RNAcentral is freely available at https://rnacentral.org.

    OriginalsprogEngelsk
    TidsskriftNucleic Acids Research
    Vol/bind47
    Udgave nummerD1
    Sider (fra-til)D221–D229
    ISSN0305-1048
    DOI
    StatusUdgivet - 2019

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