RNA antitoxins

Kenn Gerdes; E. Gerhart H. Wagner

doi:10.1016/j.mib.2007.03.003

RNA antitoxins

Kenn Gerdes, E. Gerhart H. Wagner

183 Citationer (Scopus)

Abstract

Recent genomic analyses revealed a surprisingly large number of toxin-antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin-antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR).

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Microbiology
Vol/bind	10
Udgave nummer	2
Sider (fra-til)	117-124
Antal sider	8
ISSN	1369-5274
DOI	https://doi.org/10.1016/j.mib.2007.03.003
Status	Udgivet - 2007
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/j.mib.2007.03.003

Citationsformater

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title = "RNA antitoxins",

abstract = "Recent genomic analyses revealed a surprisingly large number of toxin-antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin-antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR).",

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AU - Gerdes, Kenn

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AB - Recent genomic analyses revealed a surprisingly large number of toxin-antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin-antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR).

U2 - 10.1016/j.mib.2007.03.003

DO - 10.1016/j.mib.2007.03.003

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JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

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