Rituximab (MabThera) til behandling af aktiv reumatoid artritis

Daniel El Fassi; Claus Henrik Nielsen; Klaus Bendtzen

Rituximab (MabThera) til behandling af aktiv reumatoid artritis

Daniel El Fassi, Claus Henrik Nielsen, Klaus Bendtzen

4 Citationer (Scopus)

Abstract

Rituximab (RTX) is a murine/human monoclonal antibody to CD20, a protein expressed almost exclusively on human B-lymphocytes. RTX induces rapid and marked B-cell depletion with beneficial clinical effects in 1/3 to 1/2 of rheumatoid arthritis patients. Treatment is given as two iv. infusions with a two-week interval and in combination with methotrexate. Mild to moderate side-effects are frequent, particularly during the first infusion, but long-term side-effects are generally rare, although pulmonary events and reactivation of viral infections of the liver is of concern.

Bidragets oversatte titel	[Rituximab (MabThera) as treatment of active rheumatoid arthritis]
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	168
Udgave nummer	47
Sider (fra-til)	4079-81
Antal sider	3
ISSN	0041-5782
Status	Udgivet - 20 nov. 2006

Citationsformater

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abstract = "Rituximab (RTX) is a murine/human monoclonal antibody to CD20, a protein expressed almost exclusively on human B-lymphocytes. RTX induces rapid and marked B-cell depletion with beneficial clinical effects in 1/3 to 1/2 of rheumatoid arthritis patients. Treatment is given as two iv. infusions with a two-week interval and in combination with methotrexate. Mild to moderate side-effects are frequent, particularly during the first infusion, but long-term side-effects are generally rare, although pulmonary events and reactivation of viral infections of the liver is of concern.",

author = "{El Fassi}, Daniel and Nielsen, {Claus Henrik} and Klaus Bendtzen",

year = "2006",

month = nov,

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language = "Dansk",

volume = "168",

pages = "4079--81",

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T1 - Rituximab (MabThera) til behandling af aktiv reumatoid artritis

AU - El Fassi, Daniel

AU - Nielsen, Claus Henrik

AU - Bendtzen, Klaus

PY - 2006/11/20

Y1 - 2006/11/20

N2 - Rituximab (RTX) is a murine/human monoclonal antibody to CD20, a protein expressed almost exclusively on human B-lymphocytes. RTX induces rapid and marked B-cell depletion with beneficial clinical effects in 1/3 to 1/2 of rheumatoid arthritis patients. Treatment is given as two iv. infusions with a two-week interval and in combination with methotrexate. Mild to moderate side-effects are frequent, particularly during the first infusion, but long-term side-effects are generally rare, although pulmonary events and reactivation of viral infections of the liver is of concern.

AB - Rituximab (RTX) is a murine/human monoclonal antibody to CD20, a protein expressed almost exclusively on human B-lymphocytes. RTX induces rapid and marked B-cell depletion with beneficial clinical effects in 1/3 to 1/2 of rheumatoid arthritis patients. Treatment is given as two iv. infusions with a two-week interval and in combination with methotrexate. Mild to moderate side-effects are frequent, particularly during the first infusion, but long-term side-effects are generally rare, although pulmonary events and reactivation of viral infections of the liver is of concern.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 168

SP - 4079

EP - 4081

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 47

ER -

Rituximab (MabThera) til behandling af aktiv reumatoid artritis

Abstract

Fingeraftryk

Citationsformater