Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease

TY - JOUR

T1 - Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease

AU - Schmidt, K T

AU - Larsen, E C

AU - Andersen, C Y

AU - Andersen, A N

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Girls and young women suffering from a malignant disease that requires treatment with chemo- and/or radiotherapy are at risk of losing fertility. The most significant risk factors are age and type of treatment given. Preserving fertility is of high priority to both the young patient and her parents. This article reviews the effect of chemo- and radiotherapy on gonadal function, and thus fertility, and offers different fertility preserving methods based on the literature. Cryopreservation of ovarian tissue is a possible way of preserving fertility in this group of patients in the future.

AB - Girls and young women suffering from a malignant disease that requires treatment with chemo- and/or radiotherapy are at risk of losing fertility. The most significant risk factors are age and type of treatment given. Preserving fertility is of high priority to both the young patient and her parents. This article reviews the effect of chemo- and radiotherapy on gonadal function, and thus fertility, and offers different fertility preserving methods based on the literature. Cryopreservation of ovarian tissue is a possible way of preserving fertility in this group of patients in the future.

U2 - 10.1111/j.1471-0528.2009.02408.x

DO - 10.1111/j.1471-0528.2009.02408.x

M3 - Journal article

SN - 0140-7686

VL - 117

SP - 163

EP - 174

JO - The Journal of obstetrics and gynaecology of the British Commonwealth

JF - The Journal of obstetrics and gynaecology of the British Commonwealth

IS - 2

ER -