Risk of cancer among HIV-infected individuals compared to the background population: impact of smoking and HIV

Marie Helleberg; Jan Gerstoft; Shoaib Afzal; Gitte Kronborg; Carsten S Larsen; Court Pedersen; Stig E Bojesen; Børge G Nordestgaard; Niels Obel

doi:10.1097/QAD.0000000000000283

Risk of cancer among HIV-infected individuals compared to the background population: impact of smoking and HIV

Marie Helleberg, Jan Gerstoft, Shoaib Afzal, Gitte Kronborg, Carsten S Larsen, Court Pedersen, Stig E Bojesen, Børge G Nordestgaard, Niels Obel

Institut for Klinisk Medicin

78 Citationer (Scopus)

Abstract

BACKGROUND: The relative impact of immune deficiency and lifestyle-related factors on risk of cancer in the HIV-infected population is controversial. We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency.

METHODS: In a Danish, nationwide, population-based cohort study (1995-2011), incidences of cancer were compared between an HIV-infected cohort and a population-based matched cohort in analyses stratified on cancer category, smoking status and for HIV patients: low CD4 cell count.

RESULTS: We included 3503 HIV patients [baseline CD4+ 450 cells/μl (inter-quartile range 310-630)] and 12,979 population controls. Smoking-related and virological cancers accounted for 23 and 43% of cancers in the HIV-infected population. The risk of these cancers were higher among HIV patients compared to controls [incidence rate ratio (IRR) 2.8, 95% confidence interval (CI) 1.6-4.9; and IRR 11.5, 95% CI 6.5-20.5], whereas the risk of other cancers did not differ (IRR 1.0, 95% CI 0.7-1.3). Non-smoking HIV patients did not have increased risk of non-virological cancers compared to non-smoking controls (IRR 1.2, 95% CI 0.7-2.1). The PAFs of cancer associated with smoking and with being HIV-infected were 27 and 49%, respectively. For cancers not strongly related to smoking or viral infections, the PAFs associated with being HIV-infected and with immune deficiency were 0%.

CONCLUSION: The risk of cancer is increased in HIV patients compared to the background population. In absence of smoking, the increase in risk is confined to cancers related to viral infections, whereas the risk of other cancers is not elevated and does not seem to be associated with immune deficiency.

Originalsprog	Engelsk
Tidsskrift	AIDS (London, England)
Vol/bind	28
Udgave nummer	10
Sider (fra-til)	1499-1508
Antal sider	10
ISSN	0269-9370
DOI	https://doi.org/10.1097/QAD.0000000000000283
Status	Udgivet - 19 jun. 2014

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1097/QAD.0000000000000283

Citationsformater

@article{a584691b6beb4dcebe564d0d0b91fe76,

title = "Risk of cancer among HIV-infected individuals compared to the background population: impact of smoking and HIV",

abstract = "BACKGROUND: The relative impact of immune deficiency and lifestyle-related factors on risk of cancer in the HIV-infected population is controversial. We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency.METHODS: In a Danish, nationwide, population-based cohort study (1995-2011), incidences of cancer were compared between an HIV-infected cohort and a population-based matched cohort in analyses stratified on cancer category, smoking status and for HIV patients: low CD4 cell count.RESULTS: We included 3503 HIV patients [baseline CD4+ 450 cells/μl (inter-quartile range 310-630)] and 12,979 population controls. Smoking-related and virological cancers accounted for 23 and 43% of cancers in the HIV-infected population. The risk of these cancers were higher among HIV patients compared to controls [incidence rate ratio (IRR) 2.8, 95% confidence interval (CI) 1.6-4.9; and IRR 11.5, 95% CI 6.5-20.5], whereas the risk of other cancers did not differ (IRR 1.0, 95% CI 0.7-1.3). Non-smoking HIV patients did not have increased risk of non-virological cancers compared to non-smoking controls (IRR 1.2, 95% CI 0.7-2.1). The PAFs of cancer associated with smoking and with being HIV-infected were 27 and 49%, respectively. For cancers not strongly related to smoking or viral infections, the PAFs associated with being HIV-infected and with immune deficiency were 0%.CONCLUSION: The risk of cancer is increased in HIV patients compared to the background population. In absence of smoking, the increase in risk is confined to cancers related to viral infections, whereas the risk of other cancers is not elevated and does not seem to be associated with immune deficiency.",

keywords = "Adult, CD4 Lymphocyte Count, Cohort Studies, Denmark, Female, HIV Infections, Humans, Incidence, Male, Middle Aged, Neoplasms, Prospective Studies, Risk Assessment, Risk Factors, Smoking",

author = "Marie Helleberg and Jan Gerstoft and Shoaib Afzal and Gitte Kronborg and Larsen, {Carsten S} and Court Pedersen and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Niels Obel",

year = "2014",

month = jun,

day = "19",

doi = "10.1097/QAD.0000000000000283",

language = "English",

volume = "28",

pages = "1499--1508",

journal = "AIDS, Supplement",

issn = "1350-2840",

publisher = "Lippincott Williams & Wilkins",

number = "10",

}

TY - JOUR

T1 - Risk of cancer among HIV-infected individuals compared to the background population

T2 - impact of smoking and HIV

AU - Helleberg, Marie

AU - Gerstoft, Jan

AU - Afzal, Shoaib

AU - Kronborg, Gitte

AU - Larsen, Carsten S

AU - Pedersen, Court

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

AU - Obel, Niels

PY - 2014/6/19

Y1 - 2014/6/19

N2 - BACKGROUND: The relative impact of immune deficiency and lifestyle-related factors on risk of cancer in the HIV-infected population is controversial. We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency.METHODS: In a Danish, nationwide, population-based cohort study (1995-2011), incidences of cancer were compared between an HIV-infected cohort and a population-based matched cohort in analyses stratified on cancer category, smoking status and for HIV patients: low CD4 cell count.RESULTS: We included 3503 HIV patients [baseline CD4+ 450 cells/μl (inter-quartile range 310-630)] and 12,979 population controls. Smoking-related and virological cancers accounted for 23 and 43% of cancers in the HIV-infected population. The risk of these cancers were higher among HIV patients compared to controls [incidence rate ratio (IRR) 2.8, 95% confidence interval (CI) 1.6-4.9; and IRR 11.5, 95% CI 6.5-20.5], whereas the risk of other cancers did not differ (IRR 1.0, 95% CI 0.7-1.3). Non-smoking HIV patients did not have increased risk of non-virological cancers compared to non-smoking controls (IRR 1.2, 95% CI 0.7-2.1). The PAFs of cancer associated with smoking and with being HIV-infected were 27 and 49%, respectively. For cancers not strongly related to smoking or viral infections, the PAFs associated with being HIV-infected and with immune deficiency were 0%.CONCLUSION: The risk of cancer is increased in HIV patients compared to the background population. In absence of smoking, the increase in risk is confined to cancers related to viral infections, whereas the risk of other cancers is not elevated and does not seem to be associated with immune deficiency.

AB - BACKGROUND: The relative impact of immune deficiency and lifestyle-related factors on risk of cancer in the HIV-infected population is controversial. We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency.METHODS: In a Danish, nationwide, population-based cohort study (1995-2011), incidences of cancer were compared between an HIV-infected cohort and a population-based matched cohort in analyses stratified on cancer category, smoking status and for HIV patients: low CD4 cell count.RESULTS: We included 3503 HIV patients [baseline CD4+ 450 cells/μl (inter-quartile range 310-630)] and 12,979 population controls. Smoking-related and virological cancers accounted for 23 and 43% of cancers in the HIV-infected population. The risk of these cancers were higher among HIV patients compared to controls [incidence rate ratio (IRR) 2.8, 95% confidence interval (CI) 1.6-4.9; and IRR 11.5, 95% CI 6.5-20.5], whereas the risk of other cancers did not differ (IRR 1.0, 95% CI 0.7-1.3). Non-smoking HIV patients did not have increased risk of non-virological cancers compared to non-smoking controls (IRR 1.2, 95% CI 0.7-2.1). The PAFs of cancer associated with smoking and with being HIV-infected were 27 and 49%, respectively. For cancers not strongly related to smoking or viral infections, the PAFs associated with being HIV-infected and with immune deficiency were 0%.CONCLUSION: The risk of cancer is increased in HIV patients compared to the background population. In absence of smoking, the increase in risk is confined to cancers related to viral infections, whereas the risk of other cancers is not elevated and does not seem to be associated with immune deficiency.

KW - Adult

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Denmark

KW - Female

KW - HIV Infections

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Smoking

U2 - 10.1097/QAD.0000000000000283

DO - 10.1097/QAD.0000000000000283

M3 - Journal article

C2 - 24785952

SN - 1350-2840

VL - 28

SP - 1499

EP - 1508

JO - AIDS, Supplement

JF - AIDS, Supplement

IS - 10

ER -

Risk of cancer among HIV-infected individuals compared to the background population: impact of smoking and HIV

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater