TY - JOUR
T1 - Risk for affective disorders is associated with greater prefrontal gray matter volumes
T2 - A prospective longitudinal study
AU - Macoveanu, Julian
AU - Baaré, William
AU - Madsen, Kristoffer H
AU - Kessing, Lars Vedel
AU - Siebner, Hartwig Roman
AU - Vinberg, Maj
PY - 2018
Y1 - 2018
N2 - Background: Major depression and bipolar disorders aggregates in families and are linked with a wide range of neurobiological abnormalities including cortical gray matter (GM) alterations. Prospective studies of individuals at familial risk may expose the neural mechanisms underlying risk transmission.Methods: We used voxel based morphometry to investigate changes in regional GM brain volume, over a seven-year period, in 37 initially healthy individuals having a mono- or di-zygotic twin diagnosed with major depression or bipolar disorder (high-risk group; mean age 41.6 yrs.) as compared to 36 individuals with no history of affective disorders in the index twin and first-degree relatives (low-risk group; mean age 38.5 yrs.).Results: Groups did not differ in regional GM volume changes over time. However, independent of time, high-risk twins had significantly greater GM volumes in bilateral dorsal anterior cingulate, inferior frontal gyrus and temporoparietal regions as compared to low-risk twins. Further, individuals who developed an affective disorder at follow-up (n = 12), had relatively the largest GM volumes, both at baseline and follow-up, in the right dorsal anterior cingulate cortex and right inferior frontal cortex compared to high- and low-risk twins who remained well at follow-up.Conclusion: This pattern of apparently stable grater regional GM volume may constitute a neural marker of an increased risk for developing an affective disorder in individuals at familial risk.
AB - Background: Major depression and bipolar disorders aggregates in families and are linked with a wide range of neurobiological abnormalities including cortical gray matter (GM) alterations. Prospective studies of individuals at familial risk may expose the neural mechanisms underlying risk transmission.Methods: We used voxel based morphometry to investigate changes in regional GM brain volume, over a seven-year period, in 37 initially healthy individuals having a mono- or di-zygotic twin diagnosed with major depression or bipolar disorder (high-risk group; mean age 41.6 yrs.) as compared to 36 individuals with no history of affective disorders in the index twin and first-degree relatives (low-risk group; mean age 38.5 yrs.).Results: Groups did not differ in regional GM volume changes over time. However, independent of time, high-risk twins had significantly greater GM volumes in bilateral dorsal anterior cingulate, inferior frontal gyrus and temporoparietal regions as compared to low-risk twins. Further, individuals who developed an affective disorder at follow-up (n = 12), had relatively the largest GM volumes, both at baseline and follow-up, in the right dorsal anterior cingulate cortex and right inferior frontal cortex compared to high- and low-risk twins who remained well at follow-up.Conclusion: This pattern of apparently stable grater regional GM volume may constitute a neural marker of an increased risk for developing an affective disorder in individuals at familial risk.
KW - Adult
KW - Analysis of Variance
KW - Gray Matter/diagnostic imaging
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Middle Aged
KW - Mood Disorders/diagnostic imaging
KW - Prefrontal Cortex/pathology
KW - Prospective Studies
KW - Psychiatric Status Rating Scales
KW - Risk
KW - Time Factors
KW - Twins/genetics
U2 - 10.1016/j.nicl.2017.12.011
DO - 10.1016/j.nicl.2017.12.011
M3 - Journal article
C2 - 29527486
SN - 2213-1582
VL - 17
SP - 786
EP - 793
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -