Rho GTPases and cancer

Hui Li; Karine Peyrollier; Gülcan Kilic; Cord Herbert Brakebusch

doi:10.1002/biof.1155

Rho GTPases and cancer

Hui Li, Karine Peyrollier, Gülcan Kilic, Cord Herbert Brakebusch

40 Citationer (Scopus)

Abstract

Rho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in the interaction of tumor cells with their environment, and they are vital for the cancer supporting functions of the tumor stroma. Recent research has significantly improved our understanding of the regulation of Rho GTPase activity, the specificity of Rho GTPases, and their function in tumor stem cells and tumor stroma. This review summarizes these novel findings and tries to define challenging questions for future research.

Originalsprog	Engelsk
Tidsskrift	BioFactors (Oxford, England)
Vol/bind	40
Udgave nummer	2
Sider (fra-til)	226-35
Antal sider	10
ISSN	1872-8081
DOI	https://doi.org/10.1002/biof.1155
Status	Udgivet - mar. 2014

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10.1002/biof.1155

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@article{26a3e045185b4f9abeeaa4da0f981000,

title = "Rho GTPases and cancer",

abstract = "Rho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in the interaction of tumor cells with their environment, and they are vital for the cancer supporting functions of the tumor stroma. Recent research has significantly improved our understanding of the regulation of Rho GTPase activity, the specificity of Rho GTPases, and their function in tumor stem cells and tumor stroma. This review summarizes these novel findings and tries to define challenging questions for future research.",

author = "Hui Li and Karine Peyrollier and G{\"u}lcan Kilic and Brakebusch, {Cord Herbert}",

note = "{\textcopyright} 2013 International Union of Biochemistry and Molecular Biology.",

year = "2014",

month = mar,

doi = "10.1002/biof.1155",

language = "English",

volume = "40",

pages = "226--35",

journal = "BioFactors (Oxford, England)",

issn = "1872-8081",

publisher = "Wiley",

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TY - JOUR

T1 - Rho GTPases and cancer

AU - Li, Hui

AU - Peyrollier, Karine

AU - Kilic, Gülcan

AU - Brakebusch, Cord Herbert

PY - 2014/3

Y1 - 2014/3

N2 - Rho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in the interaction of tumor cells with their environment, and they are vital for the cancer supporting functions of the tumor stroma. Recent research has significantly improved our understanding of the regulation of Rho GTPase activity, the specificity of Rho GTPases, and their function in tumor stem cells and tumor stroma. This review summarizes these novel findings and tries to define challenging questions for future research.

AB - Rho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in the interaction of tumor cells with their environment, and they are vital for the cancer supporting functions of the tumor stroma. Recent research has significantly improved our understanding of the regulation of Rho GTPase activity, the specificity of Rho GTPases, and their function in tumor stem cells and tumor stroma. This review summarizes these novel findings and tries to define challenging questions for future research.

U2 - 10.1002/biof.1155

DO - 10.1002/biof.1155

M3 - Review

C2 - 24375503

SN - 1872-8081

VL - 40

SP - 226

EP - 235

JO - BioFactors (Oxford, England)

JF - BioFactors (Oxford, England)

IS - 2

ER -

Rho GTPases and cancer

Abstract

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