Rho GTPases and cancer

TY - JOUR

T1 - Rho GTPases and cancer

AU - Li, Hui

AU - Peyrollier, Karine

AU - Kilic, Gülcan

AU - Brakebusch, Cord Herbert

N1 - © 2013 International Union of Biochemistry and Molecular Biology.

PY - 2014/3

Y1 - 2014/3

N2 - Rho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in the interaction of tumor cells with their environment, and they are vital for the cancer supporting functions of the tumor stroma. Recent research has significantly improved our understanding of the regulation of Rho GTPase activity, the specificity of Rho GTPases, and their function in tumor stem cells and tumor stroma. This review summarizes these novel findings and tries to define challenging questions for future research.

AB - Rho GTPases are a family of small GTPases, which play an important role in the regulation of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and therefore highly important for cancer cell invasion and the formation of metastases. In addition, Rho GTPases are involved in growth and survival of tumor cells, in the interaction of tumor cells with their environment, and they are vital for the cancer supporting functions of the tumor stroma. Recent research has significantly improved our understanding of the regulation of Rho GTPase activity, the specificity of Rho GTPases, and their function in tumor stem cells and tumor stroma. This review summarizes these novel findings and tries to define challenging questions for future research.

U2 - 10.1002/biof.1155

DO - 10.1002/biof.1155

M3 - Review

C2 - 24375503

SN - 0951-6433

VL - 40

SP - 226

EP - 235

JO - BioFactors

JF - BioFactors

IS - 2

ER -