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Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors.
Charles Sylvain Demmer, David Rombach, Na Liu,
Birgitte Nielsen
,
Darryl S Pickering
,
Lennart Bunch
7
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Pharmacology, Toxicology and Pharmaceutical Science
6,7 Dinitro 2,3 Quinoxalinedione
50%
Alpha Amino 3 Hydroxy 5 Methyl 4 Isoxazolepropionic Acid
50%
Amino Acid
50%
AMPA Receptor
100%
Glutamate Receptor
100%
IC50
50%
Ionotropic Receptor
50%
N Methyl Dextro Aspartic Acid
50%
N Methyl Dextro Aspartic Acid Receptor
100%
NBQX
50%
Receptor
100%
Receptor Subtype
50%
Structure Activity Relationship
100%
Keyphrases
Amino Acids
33%
AMPA Receptor (AMPAR)
66%
Bioisoster
33%
Extensive Structure
33%
GluK1
33%
GluK3
33%
High-affinity Ligands
33%
IC50
33%
Ionotropic Receptor
100%
N-methyl-D-aspartate Receptor (NMDAR)
66%
New Analogs
33%
New Ligand
100%
Receptor Subtype Selectivity
33%
Selective Ligands
33%
Structure-activity Relationship Studies
66%