Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

Zarah Jordahn; Cheme Andersen; Anne Marie Roust Aaberg; Frank Christian Pott

doi:10.1155/2016/3185873

Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

Zarah Jordahn, Cheme Andersen, Anne Marie Roust Aaberg, Frank Christian Pott

Institut for Klinisk Medicin

Abstract

We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.

Originalsprog	Engelsk
Artikelnummer	3185873
Tidsskrift	Case Reports in Critical Care
Vol/bind	2016
Antal sider	3
ISSN	2090-6420
DOI	https://doi.org/10.1155/2016/3185873
Status	Udgivet - 2016

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10.1155/2016/3185873

Citationsformater

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abstract = "We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.",

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author = "Zarah Jordahn and Cheme Andersen and Aaberg, {Anne Marie Roust} and {Christian Pott}, Frank",

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AU - Jordahn, Zarah

AU - Andersen, Cheme

AU - Aaberg, Anne Marie Roust

AU - Christian Pott, Frank

PY - 2016

Y1 - 2016

N2 - We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.

AB - We describe the care for an elderly woman who was admitted to the intensive care unit (ICU) to receive noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease. After administration of the sleeping pill zopiclone, a nonbenzodiazepine receptor agonist (NBRA), the patient became agitated and was confused, a possible paradoxical reaction to benzodiazepines. These symptoms were immediately resolved after treatment with flumazenil, usually used to reverse the adverse effects of benzodiazepines or NBRAs and to reverse paradoxical reactions to benzodiazepines. This case indicates that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.

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DO - 10.1155/2016/3185873

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JO - Case Reports in Critical Care

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Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil

Abstract

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