Rev-erbα and the circadian transcriptional regulation of metabolism.

Z. Gerhart-Hines; M. A. Lazar

doi:10.1111/dom.12510

Rev-erbα and the circadian transcriptional regulation of metabolism.

19 Citationer (Scopus)

Abstract

The circadian clock orchestrates the co-ordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiological function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk between circadian rhythm and tissue-specific biological networks and its relevance to organismal physiology.

Originalsprog	Engelsk
Tidsskrift	Diabetes, Obesity and Metabolism Online
Vol/bind	17
Udgave nummer	S1
Sider (fra-til)	12-16
Antal sider	5
ISSN	1462-8902
DOI	https://doi.org/10.1111/dom.12510
Status	Udgivet - 1 sep. 2015

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10.1111/dom.12510

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AB - The circadian clock orchestrates the co-ordinated rhythmicity of numerous metabolic pathways to anticipate daily and seasonal changes in energy demand. This vital physiological function is controlled by a set of individual clock components that are present in each cell of the body, and regulate each other as well as clock output genes. A key factor is the nuclear receptor, Rev-erbα, a transcriptional repressor which functions not only as a clock component but also as a modulator of metabolic programming in an array of tissues. This review explores the role of Rev-erbα in mediating this crosstalk between circadian rhythm and tissue-specific biological networks and its relevance to organismal physiology.

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Rev-erbα and the circadian transcriptional regulation of metabolism.

Abstract

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