Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude

Peter Kristian Kofoed; Birgit Sander; Gustavo Zubieta-Calleja; Line Kessel; Michael Larsen; Peter Kristian Kofoed; Birgit Sander; Gustavo Zubieta-Calleja; Line Kessel; Michael Larsen

doi:10.1167/iovs.08-3217

Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude

Peter Kristian Kofoed, Birgit Sander, Gustavo Zubieta-Calleja, Line Kessel, Michael Larsen, Peter Kristian Kofoed, Birgit Sander, Gustavo Zubieta-Calleja, Line Kessel, Michael Larsen

6 Citationer (Scopus)

Abstract

PURPOSE: To examine variations in retinal vessel diameters during acclimatization of native highlanders to normobaric normoxia at sea level. METHODS: Fifteen healthy residents of the greater La Paz region in Bolivia (3600 m above sea level) were examined thrice over a 72-day period, after having traveled by airplane to Copenhagen, Denmark, near sea level. RESULTS: In the study subjects, hematocrit decreased from 49.6% (day 2) to 45.9% (P = 0.0066, day 23) and 41.7% (P <0.0001, day 72); from days 2 to 23, retinal vein diameter increased by 2.68% (P = 0.0079); whereas retinal artery and vein diameters were indistinguishable from baseline after 72 days. No funduscopic signs of retinopathy were observed. Arterial blood pressure remained stable throughout the study. CONCLUSIONS: Although a 16% reduction in hematocrit occurred between days 2 and 72 after arrival at sea level, the only significant excursion observed was that the diameter of the veins was larger at day 23 than at days 2 and 72. Retinal vessel diameters demonstrated a wide homeostatic range during acclimatization-driven hematocrit variation.

Originalsprog	Engelsk
Tidsskrift	Investigative Ophthalmology & Visual Science
Vol/bind	50
Udgave nummer	8
Sider (fra-til)	3960-3
Antal sider	4
ISSN	0146-0404
DOI	https://doi.org/10.1167/iovs.08-3217 https://doi.org/10.1167/iovs.08-3217
Status	Udgivet - 1 aug. 2009

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Kofoed, P. K., Sander, B., Zubieta-Calleja, G., Kessel, L., Larsen, M., Kofoed, P. K., Sander, B., Zubieta-Calleja, G., Kessel, L., & Larsen, M. (2009). Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude. Investigative Ophthalmology & Visual Science, 50(8), 3960-3. https://doi.org/10.1167/iovs.08-3217, https://doi.org/10.1167/iovs.08-3217

Kofoed, PK, Sander, B, Zubieta-Calleja, G, Kessel, L , Larsen, M, Kofoed, PK, Sander, B, Zubieta-Calleja, G, Kessel, L & Larsen, M 2009, 'Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude', Investigative Ophthalmology & Visual Science, bind 50, nr. 8, s. 3960-3. https://doi.org/10.1167/iovs.08-3217, https://doi.org/10.1167/iovs.08-3217

@article{a146895088ca11df928f000ea68e967b,

title = "Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude",

abstract = "PURPOSE: To examine variations in retinal vessel diameters during acclimatization of native highlanders to normobaric normoxia at sea level. METHODS: Fifteen healthy residents of the greater La Paz region in Bolivia (3600 m above sea level) were examined thrice over a 72-day period, after having traveled by airplane to Copenhagen, Denmark, near sea level. RESULTS: In the study subjects, hematocrit decreased from 49.6% (day 2) to 45.9% (P = 0.0066, day 23) and 41.7% (P <0.0001, day 72); from days 2 to 23, retinal vein diameter increased by 2.68% (P = 0.0079); whereas retinal artery and vein diameters were indistinguishable from baseline after 72 days. No funduscopic signs of retinopathy were observed. Arterial blood pressure remained stable throughout the study. CONCLUSIONS: Although a 16% reduction in hematocrit occurred between days 2 and 72 after arrival at sea level, the only significant excursion observed was that the diameter of the veins was larger at day 23 than at days 2 and 72. Retinal vessel diameters demonstrated a wide homeostatic range during acclimatization-driven hematocrit variation.",

author = "Kofoed, {Peter Kristian} and Birgit Sander and Gustavo Zubieta-Calleja and Line Kessel and Michael Larsen and Kofoed, {Peter Kristian} and Birgit Sander and Gustavo Zubieta-Calleja and Line Kessel and Michael Larsen",

note = "Keywords: Acclimatization; Adult; Altitude; Blood Pressure; Electroretinography; Female; Hematocrit; Humans; Intraocular Pressure; Male; Oxygen; Retinal Vessels; Visual Acuity",

year = "2009",

month = aug,

day = "1",

doi = "10.1167/iovs.08-3217",

language = "English",

volume = "50",

pages = "3960--3",

journal = "Investigative Ophthalmology & Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology",

number = "8",

}

TY - JOUR

T1 - Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude

AU - Kofoed, Peter Kristian

AU - Sander, Birgit

AU - Zubieta-Calleja, Gustavo

AU - Kessel, Line

AU - Larsen, Michael

AU - Kofoed, Peter Kristian

AU - Sander, Birgit

AU - Zubieta-Calleja, Gustavo

AU - Kessel, Line

AU - Larsen, Michael

N1 - Keywords: Acclimatization; Adult; Altitude; Blood Pressure; Electroretinography; Female; Hematocrit; Humans; Intraocular Pressure; Male; Oxygen; Retinal Vessels; Visual Acuity

PY - 2009/8/1

Y1 - 2009/8/1

N2 - PURPOSE: To examine variations in retinal vessel diameters during acclimatization of native highlanders to normobaric normoxia at sea level. METHODS: Fifteen healthy residents of the greater La Paz region in Bolivia (3600 m above sea level) were examined thrice over a 72-day period, after having traveled by airplane to Copenhagen, Denmark, near sea level. RESULTS: In the study subjects, hematocrit decreased from 49.6% (day 2) to 45.9% (P = 0.0066, day 23) and 41.7% (P <0.0001, day 72); from days 2 to 23, retinal vein diameter increased by 2.68% (P = 0.0079); whereas retinal artery and vein diameters were indistinguishable from baseline after 72 days. No funduscopic signs of retinopathy were observed. Arterial blood pressure remained stable throughout the study. CONCLUSIONS: Although a 16% reduction in hematocrit occurred between days 2 and 72 after arrival at sea level, the only significant excursion observed was that the diameter of the veins was larger at day 23 than at days 2 and 72. Retinal vessel diameters demonstrated a wide homeostatic range during acclimatization-driven hematocrit variation.

AB - PURPOSE: To examine variations in retinal vessel diameters during acclimatization of native highlanders to normobaric normoxia at sea level. METHODS: Fifteen healthy residents of the greater La Paz region in Bolivia (3600 m above sea level) were examined thrice over a 72-day period, after having traveled by airplane to Copenhagen, Denmark, near sea level. RESULTS: In the study subjects, hematocrit decreased from 49.6% (day 2) to 45.9% (P = 0.0066, day 23) and 41.7% (P <0.0001, day 72); from days 2 to 23, retinal vein diameter increased by 2.68% (P = 0.0079); whereas retinal artery and vein diameters were indistinguishable from baseline after 72 days. No funduscopic signs of retinopathy were observed. Arterial blood pressure remained stable throughout the study. CONCLUSIONS: Although a 16% reduction in hematocrit occurred between days 2 and 72 after arrival at sea level, the only significant excursion observed was that the diameter of the veins was larger at day 23 than at days 2 and 72. Retinal vessel diameters demonstrated a wide homeostatic range during acclimatization-driven hematocrit variation.

U2 - 10.1167/iovs.08-3217

DO - 10.1167/iovs.08-3217

M3 - Journal article

C2 - 19339736

SN - 0146-0404

VL - 50

SP - 3960

EP - 3963

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

IS - 8

ER -

Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude

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