Rethinking dog domestication by integrating genetics, archeology, and biogeography

Greger Larson; Elinor K. Karlsson; Angela Perri; Matthew T. Webster; Simon Y.W. Ho; Joris Peters; Peter W. Stahl; Philip J. Piper; Frode  Lingaas; Merete Fredholm; Kenine E. Comstock; Jaime F. Modiano; Claude Schelling; Alexander I. Agoulnik; Peter A. Leegwater; Keith Dobney; Jean-Denis Vigne; Carles  Vilà; Leif Andersson; Kerstin Lindblad-Toh

doi:10.1073/pnas.1203005109

Rethinking dog domestication by integrating genetics, archeology, and biogeography

Greger Larson, Elinor K. Karlsson, Angela Perri, Matthew T. Webster, Simon Y.W. Ho, Joris Peters, Peter W. Stahl, Philip J. Piper, Frode Lingaas, Merete Fredholm, Kenine E. Comstock, Jaime F. Modiano, Claude Schelling, Alexander I. Agoulnik, Peter A. Leegwater, Keith Dobney, Jean-Denis Vigne, Carles Vilà, Leif Andersson, Kerstin Lindblad-Toh

278 Citationer (Scopus)

Abstract

The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called "ancient" breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog's wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication.

Originalsprog	Engelsk
Tidsskrift	Proceedings of the National Academy of Sciences of the United States of America
Vol/bind	109
Udgave nummer	23
Sider (fra-til)	8878-8883
Antal sider	6
ISSN	0027-8424
DOI	https://doi.org/10.1073/pnas.1203005109
Status	Udgivet - 5 jun. 2012

Adgang til dokumentet

10.1073/pnas.1203005109

Citationsformater

Larson, G., Karlsson, E. K., Perri, A., Webster, M. T., Ho, S. Y. W., Peters, J., Stahl, P. W., Piper, P. J., Lingaas, F., Fredholm, M., Comstock, K. E., Modiano, J. F., Schelling, C., Agoulnik, A. I., Leegwater, P. A., Dobney, K., Vigne, J-D., Vilà, C., Andersson, L., & Lindblad-Toh, K. (2012). Rethinking dog domestication by integrating genetics, archeology, and biogeography. Proceedings of the National Academy of Sciences of the United States of America, 109(23), 8878-8883. https://doi.org/10.1073/pnas.1203005109

Larson, G, Karlsson, EK, Perri, A, Webster, MT, Ho, SYW, Peters, J, Stahl, PW, Piper, PJ, Lingaas, F, Fredholm, M, Comstock, KE, Modiano, JF, Schelling, C, Agoulnik, AI, Leegwater, PA, Dobney, K, Vigne, J-D, Vilà, C, Andersson, L & Lindblad-Toh, K 2012, 'Rethinking dog domestication by integrating genetics, archeology, and biogeography', Proceedings of the National Academy of Sciences of the United States of America, bind 109, nr. 23, s. 8878-8883. https://doi.org/10.1073/pnas.1203005109

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title = "Rethinking dog domestication by integrating genetics, archeology, and biogeography",

abstract = "The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called {"}ancient{"} breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog's wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication.",

author = "Greger Larson and Karlsson, {Elinor K.} and Angela Perri and Webster, {Matthew T.} and Ho, {Simon Y.W.} and Joris Peters and Stahl, {Peter W.} and Piper, {Philip J.} and Frode Lingaas and Merete Fredholm and Comstock, {Kenine E.} and Modiano, {Jaime F.} and Claude Schelling and Agoulnik, {Alexander I.} and Leegwater, {Peter A.} and Keith Dobney and Jean-Denis Vigne and Carles Vil{\`a} and Leif Andersson and Kerstin Lindblad-Toh",

year = "2012",

month = jun,

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doi = "10.1073/pnas.1203005109",

language = "English",

volume = "109",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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T1 - Rethinking dog domestication by integrating genetics, archeology, and biogeography

AU - Larson, Greger

AU - Karlsson, Elinor K.

AU - Perri, Angela

AU - Webster, Matthew T.

AU - Ho, Simon Y.W.

AU - Peters, Joris

AU - Stahl, Peter W.

AU - Piper, Philip J.

AU - Lingaas, Frode

AU - Fredholm, Merete

AU - Comstock, Kenine E.

AU - Modiano, Jaime F.

AU - Schelling, Claude

AU - Agoulnik, Alexander I.

AU - Leegwater, Peter A.

AU - Dobney, Keith

AU - Vigne, Jean-Denis

AU - Vilà, Carles

AU - Andersson, Leif

AU - Lindblad-Toh, Kerstin

PY - 2012/6/5

Y1 - 2012/6/5

N2 - The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called "ancient" breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog's wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication.

AB - The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called "ancient" breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog's wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication.

U2 - 10.1073/pnas.1203005109

DO - 10.1073/pnas.1203005109

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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