TY - JOUR
T1 - Resveratrol and inflammation
T2 - challenges in translating pre-clinical findings to improved patient outcomes
AU - Poulsen, Morten Møller
AU - Fjeldborg, Karen
AU - Ornstrup, Marie Juul
AU - Kjær, Thomas Nordstrøm
AU - Nøhr, Mark Klitgaard
AU - Pedersen, Steen Bønløkke
N1 - Copyright © 2015 Elsevier B.V. All rights reserved.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Throughout the Western world obesity prevalence is steadily increasing, and associated metabolic co-morbidities are projected to rise during the years to come. As weight loss and weight maintenance remains a major problem, new strategies to protect against obesity-related morbidity are needed. There is a clear association between obesity, low-grade inflammation and obesity-associated diseases, thus, the development of new anti-inflammatory substances is urgently needed as these may ultimately pave the way for novel treatments of obesity and lifestyle-related diseases. A candidate molecule is the polyphenolic compound resveratrol, and in the present review, we provide an overview of the field, and discuss the future scientific perspectives. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
AB - Throughout the Western world obesity prevalence is steadily increasing, and associated metabolic co-morbidities are projected to rise during the years to come. As weight loss and weight maintenance remains a major problem, new strategies to protect against obesity-related morbidity are needed. There is a clear association between obesity, low-grade inflammation and obesity-associated diseases, thus, the development of new anti-inflammatory substances is urgently needed as these may ultimately pave the way for novel treatments of obesity and lifestyle-related diseases. A candidate molecule is the polyphenolic compound resveratrol, and in the present review, we provide an overview of the field, and discuss the future scientific perspectives. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
KW - Adipose Tissue/drug effects
KW - Animals
KW - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
KW - Clinical Trials as Topic
KW - Humans
KW - Inflammation/drug therapy
KW - Obesity/drug therapy
KW - Stilbenes/pharmacology
KW - Translational Medical Research
U2 - 10.1016/j.bbadis.2014.12.024
DO - 10.1016/j.bbadis.2014.12.024
M3 - Review
C2 - 25583116
SN - 0925-4439
VL - 1852
SP - 1124
EP - 1136
JO - B B A - Molecular Basis of Disease
JF - B B A - Molecular Basis of Disease
IS - 6
ER -
