Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Maria Didriksen; Richard P Allen; Brendan J Burchell; Lise W Thørner; Andreas S Rigas; Emanuele Di Angelantonio; Maria H Nielsen; Poul J Jennum; Thomas Werge; Christian Erikstrup; Ole B Pedersen; Kaspar Nielsen; Mie T Bruun; Kristoffer S Burgdorf; Erik Sørensen; Henrik Ullum

doi:10.1016/j.sleep.2018.02.007

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Maria Didriksen, Richard P Allen, Brendan J Burchell, Lise W Thørner, Andreas S Rigas, Emanuele Di Angelantonio, Maria H Nielsen, Poul J Jennum, Thomas Werge, Christian Erikstrup, Ole B Pedersen, Kaspar Nielsen, Mie T Bruun, Kristoffer S Burgdorf, Erik Sørensen, Henrik Ullum

Institut for Klinisk Medicin

8 Citationer (Scopus)

Abstract

BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications.

METHODS: Complete data, including the Cambridge-Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women.

RESULTS: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases.

CONCLUSION: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.

Originalsprog	Engelsk
Tidsskrift	Sleep Medicine
Vol/bind	45
Sider (fra-til)	124-131
Antal sider	8
ISSN	1389-9457
DOI	https://doi.org/10.1016/j.sleep.2018.02.007
Status	Udgivet - maj 2018

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10.1016/j.sleep.2018.02.007

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Didriksen, M., Allen, R. P., Burchell, B. J., Thørner, L. W., Rigas, A. S., Di Angelantonio, E., Nielsen, M. H., Jennum, P. J., Werge, T., Erikstrup, C., Pedersen, O. B., Nielsen, K., Bruun, M. T., Burgdorf, K. S., Sørensen, E., & Ullum, H. (2018). Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors. Sleep Medicine, 45, 124-131. https://doi.org/10.1016/j.sleep.2018.02.007

Didriksen, M, Allen, RP, Burchell, BJ, Thørner, LW, Rigas, AS, Di Angelantonio, E, Nielsen, MH , Jennum, PJ , Werge, T, Erikstrup, C, Pedersen, OB, Nielsen, K, Bruun, MT, Burgdorf, KS, Sørensen, E & Ullum, H 2018, 'Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors', Sleep Medicine, bind 45, s. 124-131. https://doi.org/10.1016/j.sleep.2018.02.007

@article{66e93e02ebce40d9af2dfe5a759f4694,

title = "Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors",

abstract = "BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications.METHODS: Complete data, including the Cambridge-Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women.RESULTS: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases.CONCLUSION: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.",

author = "Maria Didriksen and Allen, {Richard P} and Burchell, {Brendan J} and Th{\o}rner, {Lise W} and Rigas, {Andreas S} and {Di Angelantonio}, Emanuele and Nielsen, {Maria H} and Jennum, {Poul J} and Thomas Werge and Christian Erikstrup and Pedersen, {Ole B} and Kaspar Nielsen and Bruun, {Mie T} and Burgdorf, {Kristoffer S} and Erik S{\o}rensen and Henrik Ullum",

year = "2018",

month = may,

doi = "10.1016/j.sleep.2018.02.007",

language = "English",

volume = "45",

pages = "124--131",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier",

}

TY - JOUR

T1 - Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

AU - Didriksen, Maria

AU - Allen, Richard P

AU - Burchell, Brendan J

AU - Thørner, Lise W

AU - Rigas, Andreas S

AU - Di Angelantonio, Emanuele

AU - Nielsen, Maria H

AU - Jennum, Poul J

AU - Werge, Thomas

AU - Erikstrup, Christian

AU - Pedersen, Ole B

AU - Nielsen, Kaspar

AU - Bruun, Mie T

AU - Burgdorf, Kristoffer S

AU - Sørensen, Erik

AU - Ullum, Henrik

PY - 2018/5

Y1 - 2018/5

N2 - BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications.METHODS: Complete data, including the Cambridge-Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women.RESULTS: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases.CONCLUSION: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.

AB - BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications.METHODS: Complete data, including the Cambridge-Hopkins RLS questionnaire, the 12-item short-form standardized health survey (SF-12), the Major Depression Inventory (MDI), body mass index, smoking status, alcohol consumption, and education were available for 24,707 participants enrolled in the Danish Blood Donor Study from May 1, 2015 to February 1, 2017. Information on quality of sleep was available for all RLS cases. T-tests and multivariable logistic regression models were applied to examine the associations of RLS and MDI scores, and the physical and mental component scores (PCS and MCS) of SF-12, respectively. Analyses were conducted separately for men and women.RESULTS: RLS associated with poorer MCS and poorer PCS. Moreover, Participants with RLS were more likely to classify with depressive disorder. Poor quality of sleep was associated with depressive disorder and poorer MCS among RLS cases, and with poorer PCS in female RLS cases.CONCLUSION: Thus, we demonstrated that RLS is associated with a significantly lower HRQL and a higher prevalence of depressive disorder among otherwise healthy individuals.

U2 - 10.1016/j.sleep.2018.02.007

DO - 10.1016/j.sleep.2018.02.007

M3 - Journal article

C2 - 29680420

SN - 1389-9457

VL - 45

SP - 124

EP - 131

JO - Sleep Medicine

JF - Sleep Medicine

ER -

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

Abstract

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