Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis

TY - JOUR

T1 - Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis

AU - Molsted, Stig

AU - Andersen, Jesper L.

AU - Eidemak, Inge

AU - Harrison, Adrian Paul

AU - Jørgensen, Niels

PY - 2014

Y1 - 2014

N2 - Background. We investigated serum testosterone and insulin-like growth factor 1 (IGF-1) levels' associations with muscle fibre size and resistance training in male dialysis patients. Methods. Male patients were included in a 16-week control period followed by 16 weeks of resistance training thrice weekly. Blood samples were obtained to analyse testosterone, luteinizing hormone (LH), IGF-1, and IGF-binding protein 3. Muscle fibres' size was analysed in biopsies from m. vastus lateralis. Results. The patients' testosterone levels were within the normal range at baseline (n=20) (19.5 (8.2-52.1) nmol/L versus 17.6 (16.1-18.0), resp.) whereas LH levels were higher (13.0 (5.5-82.8) U/L versus 4.3 (3.3-4.6), P<0.001, resp.). IGF-1 and IGF-binding protein 3 levels were higher in the patients compared with reference values (203 (59-590) ng/mL versus 151 (128-276), P=0.014, and 5045 (3370-9370) ng/mL versus 3244 (3020-3983), P<0.001, resp.). All hormone levels and muscle fibre size (n=12) remained stable throughout the study. Age-adjusted IGF-1 was associated with type 1 and 2 fibre sizes (P<0.05). Conclusion. Patients' total testosterone values were normal due to markedly increased LH values, which suggest a compensated primary insufficiency of the testosterone producing Leydig cell. Even though testosterone values were normal, resistance training was not associated with muscle hypertrophy. This trial is registered with ISRCTN72099857.

AB - Background. We investigated serum testosterone and insulin-like growth factor 1 (IGF-1) levels' associations with muscle fibre size and resistance training in male dialysis patients. Methods. Male patients were included in a 16-week control period followed by 16 weeks of resistance training thrice weekly. Blood samples were obtained to analyse testosterone, luteinizing hormone (LH), IGF-1, and IGF-binding protein 3. Muscle fibres' size was analysed in biopsies from m. vastus lateralis. Results. The patients' testosterone levels were within the normal range at baseline (n=20) (19.5 (8.2-52.1) nmol/L versus 17.6 (16.1-18.0), resp.) whereas LH levels were higher (13.0 (5.5-82.8) U/L versus 4.3 (3.3-4.6), P<0.001, resp.). IGF-1 and IGF-binding protein 3 levels were higher in the patients compared with reference values (203 (59-590) ng/mL versus 151 (128-276), P=0.014, and 5045 (3370-9370) ng/mL versus 3244 (3020-3983), P<0.001, resp.). All hormone levels and muscle fibre size (n=12) remained stable throughout the study. Age-adjusted IGF-1 was associated with type 1 and 2 fibre sizes (P<0.05). Conclusion. Patients' total testosterone values were normal due to markedly increased LH values, which suggest a compensated primary insufficiency of the testosterone producing Leydig cell. Even though testosterone values were normal, resistance training was not associated with muscle hypertrophy. This trial is registered with ISRCTN72099857.

KW - Adult

KW - Aged

KW - Exercise

KW - Humans

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Insulin-Like Growth Factor I

KW - Male

KW - Middle Aged

KW - Muscle Fibers, Skeletal

KW - Organ Size

KW - Renal Insufficiency, Chronic

KW - Testosterone

U2 - 10.1155/2014/121273

DO - 10.1155/2014/121273

M3 - Journal article

C2 - 24804194

SN - 1110-7243

VL - 2014

JO - Journal of Biomedicine and Biotechnology

JF - Journal of Biomedicine and Biotechnology

M1 - 121273

ER -