Residential exposure to plasticizers and its possible role in the pathogenesis of asthma

L Oie; Lars-Georg Hersoug; J O Madsen

Residential exposure to plasticizers and its possible role in the pathogenesis of asthma

L Oie, Lars-Georg Hersoug, J O Madsen

Afdeling for Miljø og Sundhed

206 Citationer (Scopus)

Abstract

The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.

Originalsprog	Engelsk
Tidsskrift	Environmental Health Perspectives
Vol/bind	105
Udgave nummer	9
Sider (fra-til)	972-8
Antal sider	7
ISSN	0091-6765
Status	Udgivet - sep. 1997

Citationsformater

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title = "Residential exposure to plasticizers and its possible role in the pathogenesis of asthma",

abstract = "The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.",

keywords = "Aerosols, Air Pollution, Indoor, Asthma, Child, Child, Preschool, Diethylhexyl Phthalate, Environmental Exposure, Female, Housing, Humans, Inflammation, Inhalation Exposure, Male",

author = "L Oie and Lars-Georg Hersoug and Madsen, {J O}",

year = "1997",

month = sep,

language = "English",

volume = "105",

pages = "972--8",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "National Institute of Environmental Health Sciences",

number = "9",

}

TY - JOUR

T1 - Residential exposure to plasticizers and its possible role in the pathogenesis of asthma

AU - Oie, L

AU - Hersoug, Lars-Georg

AU - Madsen, J O

PY - 1997/9

Y1 - 1997/9

N2 - The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.

AB - The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.

KW - Aerosols

KW - Air Pollution, Indoor

KW - Asthma

KW - Child

KW - Child, Preschool

KW - Diethylhexyl Phthalate

KW - Environmental Exposure

KW - Female

KW - Housing

KW - Humans

KW - Inflammation

KW - Inhalation Exposure

KW - Male

M3 - Journal article

C2 - 9374082

SN - 0091-6765

VL - 105

SP - 972

EP - 978

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 9

ER -

Residential exposure to plasticizers and its possible role in the pathogenesis of asthma

Abstract

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