TY - JOUR
T1 - Reproductive profiles and risk of breast cancer subtypes
T2 - A multi-center case-only study
AU - Brouckaert, Olivier
AU - Rudolph, Anja
AU - Laenen, Annouschka
AU - Keeman, Renske
AU - Bolla, Manjeet K.
AU - Wang, Qin
AU - Soubry, Adelheid
AU - Wildiers, Hans
AU - Andrulis, Irene L.
AU - Arndt, Volker
AU - Beckmann, Matthias W.
AU - Benitez, Javier
AU - Blomqvist, Carl
AU - Bojesen, Stig E.
AU - Brauch, Hiltrud
AU - Brennan, Paul
AU - Brenner, Hermann
AU - Chenevix-Trench, Georgia
AU - Choi, Ji Yeob
AU - Cornelissen, Sten
AU - Couch, Fergus J.
AU - Cox, Angela
AU - Cross, Simon S.
AU - Czene, Kamila
AU - Eriksson, Mikael
AU - Fasching, Peter A.
AU - Figueroa, Jonine
AU - Flyger, Henrik
AU - Giles, Graham G.
AU - González-Neira, Anna
AU - Guénel, Pascal
AU - Hall, Per
AU - Hollestelle, Antoinette
AU - Hopper, John L.
AU - Ito, Hidemi
AU - Jones, Michael
AU - Kang, Daehee
AU - kConFab
AU - Knight, Julia A.
AU - Kosma, Veli Matti
AU - Li, Jingmei
AU - Lindblom, Annika
AU - Lilyquist, Jenna
AU - Lophatananon, Artitaya
AU - Mannermaa, Arto
AU - Manoukian, Siranoush
AU - Margolin, Sara
AU - Matsuo, Keitaro
AU - Muir, Kenneth
AU - Nevanlinna, Heli
AU - Peterlongo, Paolo
AU - Change-Claude, Jenny
AU - Lambrechts, Diether
AU - Neven, Patrick
PY - 2017/11/7
Y1 - 2017/11/7
N2 - Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.
AB - Background: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Methods: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. Results: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. Conclusions: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.
KW - Age at breast cancer diagnosis
KW - Age at first full-time pregnancy
KW - Age at menarche
KW - Breast cancer subtype
KW - Parity
U2 - 10.1186/s13058-017-0909-3
DO - 10.1186/s13058-017-0909-3
M3 - Journal article
C2 - 29116004
AN - SCOPUS:85033407313
SN - 1465-5411
VL - 19
JO - Breast Cancer Research
JF - Breast Cancer Research
M1 - 119
ER -
