Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition

Babette L R Reijs; Inez H G B Ramakers; Lyzel Elias-Sonnenschein; Charlotte E Teunissen; Marleen Koel-Simmelink; Magda Tsolaki; Lars-Olof Wahlund; Gunhild Waldemar; Lucrezia Hausner; Peter Johannsen; Hugo Vanderstichele; Frans Verhey; D P Devanand; Pieter Jelle Visser

doi:10.3233/JAD-170564

Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition

Babette L R Reijs, Inez H G B Ramakers, Lyzel Elias-Sonnenschein, Charlotte E Teunissen, Marleen Koel-Simmelink, Magda Tsolaki, Lars-Olof Wahlund, Gunhild Waldemar, Lucrezia Hausner, Peter Johannsen, Hugo Vanderstichele, Frans Verhey, D P Devanand, Pieter Jelle Visser

Institut for Klinisk Medicin

16 Citationer (Scopus)

Abstract

Background: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). Objective: To investigate the association between odor identification and amyloid-β 1-42 (Aβ₄₂) and total tau (t-Tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF Aβ₄₂ and t-Tau and apolipoprotein E (APOE) genotype. Methods: We included 160 individuals (40 with normal cognition, 45 with mild cognitive impairment (MCI), 42 with ADtype dementia, and 26 individuals with non-AD dementia) from the EDAR study. Individuals were recruited from six memory clinics across Europe. Odor identification was tested with the brief University of Pennsylvania Smell Identification Test. CSF A-42 and t-Tau were assessed with INNO-BIA AlzBio3 Luminex assay. Neuropsychological assessment included tests for verbal memory, verbal fluency, attention, executive function, and visuoconstruction. Follow-up was performed within 3 years after baseline. Results: Lower odor identification scores correlated with increased CSF t-Tau concentrations and with lower scores on all cognitive measures at baseline independent of diagnostic group. Lower odor identification scores predicted decline on the MMSE in the total group, and decline on wordlist learning and delayed recall in APOE β4 carriers and in individuals with abnormal Aβ₄₂. Conclusion: Odor identification impairment may be an indicator of neuronal injury rather than amyloid pathology.

Originalsprog	Engelsk
Tidsskrift	Journal of Alzheimer's Disease
Vol/bind	60
Udgave nummer	3
Sider (fra-til)	1025-1034
Antal sider	10
ISSN	1387-2877
DOI	https://doi.org/10.3233/JAD-170564
Status	Udgivet - 2017

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10.3233/JAD-170564

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Reijs, B. L. R., Ramakers, I. H. G. B., Elias-Sonnenschein, L., Teunissen, C. E., Koel-Simmelink, M., Tsolaki, M., Wahlund, L-O., Waldemar, G., Hausner, L., Johannsen, P., Vanderstichele, H., Verhey, F., Devanand, D. P., & Visser, P. J. (2017). Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition. Journal of Alzheimer's Disease, 60(3), 1025-1034. https://doi.org/10.3233/JAD-170564

Reijs, BLR, Ramakers, IHGB, Elias-Sonnenschein, L, Teunissen, CE, Koel-Simmelink, M, Tsolaki, M, Wahlund, L-O, Waldemar, G, Hausner, L, Johannsen, P, Vanderstichele, H, Verhey, F, Devanand, DP & Visser, PJ 2017, 'Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition', Journal of Alzheimer's Disease, bind 60, nr. 3, s. 1025-1034. https://doi.org/10.3233/JAD-170564

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title = "Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition",

abstract = "Background: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). Objective: To investigate the association between odor identification and amyloid-β 1-42 (Aβ42) and total tau (t-Tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF Aβ42 and t-Tau and apolipoprotein E (APOE) genotype. Methods: We included 160 individuals (40 with normal cognition, 45 with mild cognitive impairment (MCI), 42 with ADtype dementia, and 26 individuals with non-AD dementia) from the EDAR study. Individuals were recruited from six memory clinics across Europe. Odor identification was tested with the brief University of Pennsylvania Smell Identification Test. CSF A-42 and t-Tau were assessed with INNO-BIA AlzBio3 Luminex assay. Neuropsychological assessment included tests for verbal memory, verbal fluency, attention, executive function, and visuoconstruction. Follow-up was performed within 3 years after baseline. Results: Lower odor identification scores correlated with increased CSF t-Tau concentrations and with lower scores on all cognitive measures at baseline independent of diagnostic group. Lower odor identification scores predicted decline on the MMSE in the total group, and decline on wordlist learning and delayed recall in APOE β4 carriers and in individuals with abnormal Aβ42. Conclusion: Odor identification impairment may be an indicator of neuronal injury rather than amyloid pathology.",

keywords = "Journal Article",

author = "Reijs, {Babette L R} and Ramakers, {Inez H G B} and Lyzel Elias-Sonnenschein and Teunissen, {Charlotte E} and Marleen Koel-Simmelink and Magda Tsolaki and Lars-Olof Wahlund and Gunhild Waldemar and Lucrezia Hausner and Peter Johannsen and Hugo Vanderstichele and Frans Verhey and Devanand, {D P} and Visser, {Pieter Jelle}",

year = "2017",

doi = "10.3233/JAD-170564",

language = "English",

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pages = "1025--1034",

journal = "Journal of Alzheimer's Disease",

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TY - JOUR

T1 - Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition

AU - Reijs, Babette L R

AU - Ramakers, Inez H G B

AU - Elias-Sonnenschein, Lyzel

AU - Teunissen, Charlotte E

AU - Koel-Simmelink, Marleen

AU - Tsolaki, Magda

AU - Wahlund, Lars-Olof

AU - Waldemar, Gunhild

AU - Hausner, Lucrezia

AU - Johannsen, Peter

AU - Vanderstichele, Hugo

AU - Verhey, Frans

AU - Devanand, D P

AU - Visser, Pieter Jelle

PY - 2017

Y1 - 2017

N2 - Background: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). Objective: To investigate the association between odor identification and amyloid-β 1-42 (Aβ42) and total tau (t-Tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF Aβ42 and t-Tau and apolipoprotein E (APOE) genotype. Methods: We included 160 individuals (40 with normal cognition, 45 with mild cognitive impairment (MCI), 42 with ADtype dementia, and 26 individuals with non-AD dementia) from the EDAR study. Individuals were recruited from six memory clinics across Europe. Odor identification was tested with the brief University of Pennsylvania Smell Identification Test. CSF A-42 and t-Tau were assessed with INNO-BIA AlzBio3 Luminex assay. Neuropsychological assessment included tests for verbal memory, verbal fluency, attention, executive function, and visuoconstruction. Follow-up was performed within 3 years after baseline. Results: Lower odor identification scores correlated with increased CSF t-Tau concentrations and with lower scores on all cognitive measures at baseline independent of diagnostic group. Lower odor identification scores predicted decline on the MMSE in the total group, and decline on wordlist learning and delayed recall in APOE β4 carriers and in individuals with abnormal Aβ42. Conclusion: Odor identification impairment may be an indicator of neuronal injury rather than amyloid pathology.

AB - Background: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). Objective: To investigate the association between odor identification and amyloid-β 1-42 (Aβ42) and total tau (t-Tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF Aβ42 and t-Tau and apolipoprotein E (APOE) genotype. Methods: We included 160 individuals (40 with normal cognition, 45 with mild cognitive impairment (MCI), 42 with ADtype dementia, and 26 individuals with non-AD dementia) from the EDAR study. Individuals were recruited from six memory clinics across Europe. Odor identification was tested with the brief University of Pennsylvania Smell Identification Test. CSF A-42 and t-Tau were assessed with INNO-BIA AlzBio3 Luminex assay. Neuropsychological assessment included tests for verbal memory, verbal fluency, attention, executive function, and visuoconstruction. Follow-up was performed within 3 years after baseline. Results: Lower odor identification scores correlated with increased CSF t-Tau concentrations and with lower scores on all cognitive measures at baseline independent of diagnostic group. Lower odor identification scores predicted decline on the MMSE in the total group, and decline on wordlist learning and delayed recall in APOE β4 carriers and in individuals with abnormal Aβ42. Conclusion: Odor identification impairment may be an indicator of neuronal injury rather than amyloid pathology.

KW - Journal Article

U2 - 10.3233/JAD-170564

DO - 10.3233/JAD-170564

M3 - Journal article

C2 - 28984603

SN - 1387-2877

VL - 60

SP - 1025

EP - 1034

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 3

ER -

Relation of Odor Identification with Alzheimer's Disease Markers in Cerebrospinal Fluid and Cognition

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