RelateAdmix: a software tool for estimating relatedness between admixed individuals

TY - JOUR

T1 - RelateAdmix

T2 - a software tool for estimating relatedness between admixed individuals

AU - Moltke, Ida

AU - Albrechtsen, Anders

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Motivation: Pairwise relatedness plays an important role in a range of genetic research fields. However, currently only few estimators exist for individuals that are admixed, i.e. have ancestry from more than one population, and these estimators fail in some situations.Results: We present a new software tool, RelateAdmix, for obtaining maximum likelihood estimates of pairwise relatedness from genetic data between admixed individuals. We show using simulated data that it gives rise to better estimates than three state-of-the-art software tools, REAP, KING and Plink, while still being fast enough to be applicable to large datasets.

AB - Motivation: Pairwise relatedness plays an important role in a range of genetic research fields. However, currently only few estimators exist for individuals that are admixed, i.e. have ancestry from more than one population, and these estimators fail in some situations.Results: We present a new software tool, RelateAdmix, for obtaining maximum likelihood estimates of pairwise relatedness from genetic data between admixed individuals. We show using simulated data that it gives rise to better estimates than three state-of-the-art software tools, REAP, KING and Plink, while still being fast enough to be applicable to large datasets.

U2 - 10.1093/bioinformatics/btt652

DO - 10.1093/bioinformatics/btt652

M3 - Journal article

C2 - 24215025

SN - 1367-4803

VL - 30

SP - 1027

EP - 1028

JO - Bioinformatics

JF - Bioinformatics

IS - 7

ER -