Regulering af cytokindannelse ved inflammatoriske tarmsygdomme

Laura Ferrero-Miliani; Jakob Benecidt Seidelin; Ole Haagen Nielsen

Regulering af cytokindannelse ved inflammatoriske tarmsygdomme

Laura Ferrero-Miliani, Jakob Benecidt Seidelin, Ole Haagen Nielsen

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.

Bidragets oversatte titel	Regulation of cytokine production in inflammatory bowel disease
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	168
Udgave nummer	19
Sider (fra-til)	1847-50
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 8 maj 2006

Emneord

Caspase 1
Colitis, Ulcerative
Cytokines
Enzyme Activation
Humans
Multiprotein Complexes

Citationsformater

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title = "Regulering af cytokindannelse ved inflammatoriske tarmsygdomme",

abstract = "Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.",

keywords = "Caspase 1, Colitis, Ulcerative, Cytokines, Enzyme Activation, Humans, Multiprotein Complexes, English Abstract, Journal Article, Review",

author = "Laura Ferrero-Miliani and Seidelin, {Jakob Benecidt} and Nielsen, {Ole Haagen}",

year = "2006",

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language = "Dansk",

volume = "168",

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T1 - Regulering af cytokindannelse ved inflammatoriske tarmsygdomme

AU - Ferrero-Miliani, Laura

AU - Seidelin, Jakob Benecidt

AU - Nielsen, Ole Haagen

PY - 2006/5/8

Y1 - 2006/5/8

N2 - Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.

AB - Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.

KW - Caspase 1

KW - Colitis, Ulcerative

KW - Cytokines

KW - Enzyme Activation

KW - Humans

KW - Multiprotein Complexes

KW - English Abstract

KW - Journal Article

KW - Review

M3 - Tidsskriftartikel

C2 - 16756799

SN - 0041-5782

VL - 168

SP - 1847

EP - 1850

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 19

ER -

Regulering af cytokindannelse ved inflammatoriske tarmsygdomme

Abstract

Emneord

Fingeraftryk

Citationsformater