Regulation of pqs quorum sensing via catabolite repression control in Pseudomonas aeruginosa

Lianbo Zhang; Qingguo Gao; Wanying Chen; Haiyan Qin; Hengzhuang Wang; Yicai Chen; Liang Yang; Guang Zhang

doi:10.1099/mic.0.066266-0

Regulation of pqs quorum sensing via catabolite repression control in Pseudomonas aeruginosa

Lianbo Zhang, Qingguo Gao, Wanying Chen, Haiyan Qin, Hengzhuang Wang, Yicai Chen, Liang Yang, Guang Zhang

20 Citationer (Scopus)

Abstract

Bacteria have evolved a set of regulatory pathways to adapt to the dynamic nutritional environment during the course of infection. However, the underlying mechanism of the regulatory effects by nutritional cues on bacterial pathogenesis is unclear. In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. Our study suggests that deregulation of the catabolite repression by P. aeruginosa might enhance its fitness during cystic fibrosis infections.

Originalsprog	Engelsk
Tidsskrift	Microbiology
Vol/bind	159
Udgave nummer	Pt 9
Sider (fra-til)	1931-6
Antal sider	6
ISSN	1350-0872
DOI	https://doi.org/10.1099/mic.0.066266-0
Status	Udgivet - 1 sep. 2013

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10.1099/mic.0.066266-0

Citationsformater

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title = "Regulation of pqs quorum sensing via catabolite repression control in Pseudomonas aeruginosa",

abstract = "Bacteria have evolved a set of regulatory pathways to adapt to the dynamic nutritional environment during the course of infection. However, the underlying mechanism of the regulatory effects by nutritional cues on bacterial pathogenesis is unclear. In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. Our study suggests that deregulation of the catabolite repression by P. aeruginosa might enhance its fitness during cystic fibrosis infections.",

keywords = "Animals, Bacterial Proteins, Biofilms, Catabolite Repression, Female, Gene Expression Regulation, Bacterial, Humans, Mice, Mice, Inbred BALB C, Pseudomonas Infections, Pseudomonas aeruginosa, Pyocyanine, Quinolones, Quorum Sensing, Repressor Proteins, Virulence Factors",

author = "Lianbo Zhang and Qingguo Gao and Wanying Chen and Haiyan Qin and Hengzhuang Wang and Yicai Chen and Liang Yang and Guang Zhang",

year = "2013",

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doi = "10.1099/mic.0.066266-0",

language = "English",

volume = "159",

pages = "1931--6",

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publisher = "Society for General Microbiology",

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TY - JOUR

T1 - Regulation of pqs quorum sensing via catabolite repression control in Pseudomonas aeruginosa

AU - Zhang, Lianbo

AU - Gao, Qingguo

AU - Chen, Wanying

AU - Qin, Haiyan

AU - Wang, Hengzhuang

AU - Chen, Yicai

AU - Yang, Liang

AU - Zhang, Guang

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Bacteria have evolved a set of regulatory pathways to adapt to the dynamic nutritional environment during the course of infection. However, the underlying mechanism of the regulatory effects by nutritional cues on bacterial pathogenesis is unclear. In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. Our study suggests that deregulation of the catabolite repression by P. aeruginosa might enhance its fitness during cystic fibrosis infections.

AB - Bacteria have evolved a set of regulatory pathways to adapt to the dynamic nutritional environment during the course of infection. However, the underlying mechanism of the regulatory effects by nutritional cues on bacterial pathogenesis is unclear. In the present study, we showed that the Pseudomonas aeruginosa catabolite repression control protein regulates the Pseudomonas quinolone signal quorum sensing, which further controls synthesis of virulence factor pyocyanin, biofilm formation and survival during infection models. Our study suggests that deregulation of the catabolite repression by P. aeruginosa might enhance its fitness during cystic fibrosis infections.

KW - Animals

KW - Bacterial Proteins

KW - Biofilms

KW - Catabolite Repression

KW - Female

KW - Gene Expression Regulation, Bacterial

KW - Humans

KW - Mice

KW - Mice, Inbred BALB C

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Pyocyanine

KW - Quinolones

KW - Quorum Sensing

KW - Repressor Proteins

KW - Virulence Factors

U2 - 10.1099/mic.0.066266-0

DO - 10.1099/mic.0.066266-0

M3 - Journal article

C2 - 23831999

SN - 1350-0872

VL - 159

SP - 1931

EP - 1936

JO - Microbiology

JF - Microbiology

IS - Pt 9

ER -

Regulation of pqs quorum sensing via catabolite repression control in Pseudomonas aeruginosa

Abstract

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