Regulation of human neutrophil granule protein expression.

TY - JOUR

T1 - Regulation of human neutrophil granule protein expression.

AU - Borregaard, N

AU - Theilgaard-Mönch, K

AU - Sørensen, O E

AU - Cowland, J B

N1 - Keywords: Blood Proteins; Cytoplasmic Granules; Humans; Neutrophil Activation; Neutrophils

PY - 2001

Y1 - 2001

N2 - The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression.

AB - The function of the mature polymorphonuclear neutrophil is dependent on its granules, each with its characteristic content of proteins. The granule proteins are formed at different stages during maturation of neutrophils from myeloblasts to segmented cells. The regulation of granule protein expression is controlled by a number of transcription factors, many of which are also essential for commitment of multipotent hematopoietic stem cells to lineage-committed myeloid progenitor cells and for differentiation of these progenitor cells; among these, PU.1 and C/EBPalpha stand out as critical for all granule proteins whereas AML-1 is critical for primary granule protein expression and C/EBPepsilon for secondary and tertiary granule protein expression.

M3 - Journal article

C2 - 11138622

SN - 1065-6251

VL - 8

SP - 23

EP - 27

JO - Current Opinion in Hematology

JF - Current Opinion in Hematology

IS - 1

ER -