Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans.

TY - JOUR

T1 - Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans.

AU - Yoneda, Atsuko

AU - Couchman, John R

N1 - Keywords: Actins; Amino Acid Sequence; Animals; Cytoskeleton; Focal Adhesions; Humans; Integrins; Membrane Glycoproteins; Molecular Sequence Data; Neurites; Proteoglycans; Syndecans

PY - 2003

Y1 - 2003

N2 - Syndecans, a family of transmembrane proteoglycans, interact with numerous extracellular ligands through specific sequences in their heparan sulfate chains and have been considered to be co-receptors for matrix molecules and growth factors. In addition to their roles as co-receptors, many studies have recently suggested that signaling through core protein of syndecans can regulate cytoskeletal organization through their clustering, association with cytoskeletal structures, binding to cytoplasmic binding proteins, and intracellular phosphorylation. Here we will review current understanding of signaling through syndecans in cytoskeletal organization.

AB - Syndecans, a family of transmembrane proteoglycans, interact with numerous extracellular ligands through specific sequences in their heparan sulfate chains and have been considered to be co-receptors for matrix molecules and growth factors. In addition to their roles as co-receptors, many studies have recently suggested that signaling through core protein of syndecans can regulate cytoskeletal organization through their clustering, association with cytoskeletal structures, binding to cytoplasmic binding proteins, and intracellular phosphorylation. Here we will review current understanding of signaling through syndecans in cytoskeletal organization.

M3 - Journal article

C2 - 12714039

SN - 0945-053X

VL - 22

SP - 25

EP - 33

JO - Matrix Biology

JF - Matrix Biology

IS - 1

ER -