Regulation and Function of AQP4 in the Central Nervous System

Mette Assentoft; Brian Roland Larsen; Nanna MacAulay

doi:10.1007/s11064-015-1519-z

Regulation and Function of AQP4 in the Central Nervous System

Mette Assentoft, Brian Roland Larsen, Nanna MacAulay

ICMM Afdeling 8

27 Citationer (Scopus)

Abstract

Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.

Originalsprog	Engelsk
Tidsskrift	Neurochemical Research
Vol/bind	40
Udgave nummer	12
Sider (fra-til)	2615-2627
Antal sider	13
ISSN	0364-3190
DOI	https://doi.org/10.1007/s11064-015-1519-z
Status	Udgivet - 1 dec. 2015

Adgang til dokumentet

10.1007/s11064-015-1519-z

Citationsformater

@article{d574f7c72ce84b30a6937e49f8a366ad,

title = "Regulation and Function of AQP4 in the Central Nervous System",

abstract = "Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.",

author = "Mette Assentoft and Larsen, {Brian Roland} and Nanna MacAulay",

year = "2015",

month = dec,

day = "1",

doi = "10.1007/s11064-015-1519-z",

language = "English",

volume = "40",

pages = "2615--2627",

journal = "Neurochemical Research",

issn = "0364-3190",

publisher = "Springer",

number = "12",

}

TY - JOUR

T1 - Regulation and Function of AQP4 in the Central Nervous System

AU - Assentoft, Mette

AU - Larsen, Brian Roland

AU - MacAulay, Nanna

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.

AB - Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation. Conflicting data have been presented on the role of AQP4 in K(+) clearance and associated extracellular space shrinkage and on the stroke-induced alterations of AQP4 expression levels during edema formation, raising questions about the functional importance of AQP4 in these (patho)physiological aspects. Phosphorylation-dependent gating of AQP4 has been proposed as a regulatory mechanism for AQP4-mediated osmotic water transport. This paradigm was, however, recently challenged by experimental evidence and molecular dynamics simulations. Regulatory patterns and physiological roles for AQP4 thus remain to be fully explored.

U2 - 10.1007/s11064-015-1519-z

DO - 10.1007/s11064-015-1519-z

M3 - Journal article

C2 - 25630715

SN - 0364-3190

VL - 40

SP - 2615

EP - 2627

JO - Neurochemical Research

JF - Neurochemical Research

IS - 12

ER -

Regulation and Function of AQP4 in the Central Nervous System

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater