TY - JOUR
T1 - Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study
AU - Thomsen, Simon Francis
AU - Kyvik, Kirsten Ohm
AU - Skadhauge, Lars Rauff
AU - Steffensen, Ida
AU - Backer, Vibeke
N1 - Keywords: Adolescent; Adult; Age Distribution; Age of Onset; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Confidence Intervals; Cross-Sectional Studies; Denmark; Diseases in Twins; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Odds Ratio; Prevalence; Probability; Questionnaires; Reference Values; Risk Assessment; Sex Distribution; Young Adult
PY - 2009/4/1
Y1 - 2009/4/1
N2 - BACKGROUND: Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry. RESULTS: We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002. CONCLUSIONS: Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma.
AB - BACKGROUND: Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry. RESULTS: We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002. CONCLUSIONS: Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma.
U2 - 10.1111/j.1752-699X.2008.00113.x
DO - 10.1111/j.1752-699X.2008.00113.x
M3 - Journal article
C2 - 20298382
SN - 1752-6981
VL - 3
SP - 82
EP - 84
JO - Clinical Respiratory Journal
JF - Clinical Respiratory Journal
IS - 2
ER -