Reference values for serum total adiponectin in healthy non-obese children and adolescents

Ulrik Lausten-Thomsen; Michael Christiansen; Cilius Esmann Fonvig; Cæcilie Trier; Oluf Pedersen; Torben Hansen; Jens-Christian Holm

doi:10.1016/j.cca.2015.07.012

Reference values for serum total adiponectin in healthy non-obese children and adolescents

Ulrik Lausten-Thomsen, Michael Christiansen, Cilius Esmann Fonvig, Cæcilie Trier, Oluf Pedersen, Torben Hansen, Jens-Christian Holm

Institut for Klinisk Medicin

21 Citationer (Scopus)

Abstract

Background: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels. Methods: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18. years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization. Results: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p. <. 0.0001) and boys (p = <. 0.0001) and for both sexes combined (p. <. 0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y = - 0.1478 * X + 6.046; 2.5th percentile: Y = - 0.06256 * X + 2.34; 97.5th percentile: Y = - 0.4086 * X + 22.39, where Y = adiponectin in μg/mL and X = years of age (from 6 to 18. years). Conclusion: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18. years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.

Originalsprog	Engelsk
Tidsskrift	Clinica Chimica Acta
Vol/bind	450
Sider (fra-til)	11-4
Antal sider	4
ISSN	0009-8981
DOI	https://doi.org/10.1016/j.cca.2015.07.012
Status	Udgivet - 3 okt. 2015

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title = "Reference values for serum total adiponectin in healthy non-obese children and adolescents",

abstract = "Background: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels. Methods: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18. years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet{\textregistered} ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization. Results: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p. <. 0.0001) and boys (p = <. 0.0001) and for both sexes combined (p. <. 0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y = - 0.1478 * X + 6.046; 2.5th percentile: Y = - 0.06256 * X + 2.34; 97.5th percentile: Y = - 0.4086 * X + 22.39, where Y = adiponectin in μg/mL and X = years of age (from 6 to 18. years). Conclusion: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18. years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.",

author = "Ulrik Lausten-Thomsen and Michael Christiansen and Fonvig, {Cilius Esmann} and C{\ae}cilie Trier and Oluf Pedersen and Torben Hansen and Jens-Christian Holm",

note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",

year = "2015",

month = oct,

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doi = "10.1016/j.cca.2015.07.012",

language = "English",

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journal = "Clinica Chimica Acta",

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TY - JOUR

T1 - Reference values for serum total adiponectin in healthy non-obese children and adolescents

AU - Lausten-Thomsen, Ulrik

AU - Christiansen, Michael

AU - Fonvig, Cilius Esmann

AU - Trier, Cæcilie

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Holm, Jens-Christian

PY - 2015/10/3

Y1 - 2015/10/3

N2 - Background: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels. Methods: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18. years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization. Results: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p. <. 0.0001) and boys (p = <. 0.0001) and for both sexes combined (p. <. 0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y = - 0.1478 * X + 6.046; 2.5th percentile: Y = - 0.06256 * X + 2.34; 97.5th percentile: Y = - 0.4086 * X + 22.39, where Y = adiponectin in μg/mL and X = years of age (from 6 to 18. years). Conclusion: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18. years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.

AB - Background: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels. Methods: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18. years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization. Results: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p. <. 0.0001) and boys (p = <. 0.0001) and for both sexes combined (p. <. 0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y = - 0.1478 * X + 6.046; 2.5th percentile: Y = - 0.06256 * X + 2.34; 97.5th percentile: Y = - 0.4086 * X + 22.39, where Y = adiponectin in μg/mL and X = years of age (from 6 to 18. years). Conclusion: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18. years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.

U2 - 10.1016/j.cca.2015.07.012

DO - 10.1016/j.cca.2015.07.012

M3 - Journal article

C2 - 26169157

SN - 0009-8981

VL - 450

SP - 11

EP - 14

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

Reference values for serum total adiponectin in healthy non-obese children and adolescents

Abstract

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