Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study

TY - JOUR

T1 - Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study

AU - Drummen, Mathijs

AU - Heinecke, Alexander

AU - Dorenbos, Elke

AU - Vreugdenhil, Anita

AU - Raben, Anne

AU - Westerterp-Plantenga, M S

AU - Adam, Tanja C

N1 - CURIS 2019 NEXS 225 Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Introduction: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness. Methods: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period. Results: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = −0.42; p =.049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p <.01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p <.01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p <.01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p <.01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume. Conclusion: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness. Trial registration: The trial is registered with ClinicalTrials.gov, NCT01777893.

AB - Introduction: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness. Methods: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period. Results: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = −0.42; p =.049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p <.01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p <.01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p <.01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p <.01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume. Conclusion: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness. Trial registration: The trial is registered with ClinicalTrials.gov, NCT01777893.

KW - Faculty of Science

KW - MRI

KW - Cortical thickness

KW - Grey matter volume

KW - BMI

KW - Insulin resistance

KW - Weight loss

U2 - 10.1016/j.jns.2019.06.017

DO - 10.1016/j.jns.2019.06.017

M3 - Journal article

C2 - 31255969

SN - 0022-510X

VL - 403

SP - 106

EP - 111

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

ER -