Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients

TY - JOUR

T1 - Reduction of common motoneuronal drive on the affected side during walking in hemiplegic stroke patients

AU - Nielsen, Jens Bo

AU - Brittain, John-Stuart

AU - Halliday, David M.

AU - Marchand-Pauvert, Véronique

AU - Mazevet, D.

AU - Conway, Bernard A.

N1 - CURIS 2008 5200 145

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The objective of this study was to use motor unit coupling in the time and frequency domains to obtain evidence of changes in motoneuronal drive during walking in subjects with stroke. METHODS: Paired tibialis anterior (TA) EMG activity was sampled during the swing phase of treadmill walking in eight subjects with unilateral stroke. RESULTS: On the unaffected side, short-term synchronization was evident from the presence of a narrow central peak in cumulant densities and from the presence of significant coherence between these signals in the 10-25 Hz band. Such indicators of short-term synchrony were either absent or very small on the affected side. Instead, pronounced 10 Hz coupling was observed. CONCLUSIONS: It is suggested that reduced corticospinal drive to the spinal motoneurones is responsible for the reduced short-term synchrony and coherence in the 10-25 Hz frequency band on the affected side in hemiplegic patients during walking. SIGNIFICANCE: This is of importance for understanding the mechanisms responsible for reduced gait ability and development of new strategies for gait restoration.

AB - OBJECTIVE: The objective of this study was to use motor unit coupling in the time and frequency domains to obtain evidence of changes in motoneuronal drive during walking in subjects with stroke. METHODS: Paired tibialis anterior (TA) EMG activity was sampled during the swing phase of treadmill walking in eight subjects with unilateral stroke. RESULTS: On the unaffected side, short-term synchronization was evident from the presence of a narrow central peak in cumulant densities and from the presence of significant coherence between these signals in the 10-25 Hz band. Such indicators of short-term synchrony were either absent or very small on the affected side. Instead, pronounced 10 Hz coupling was observed. CONCLUSIONS: It is suggested that reduced corticospinal drive to the spinal motoneurones is responsible for the reduced short-term synchrony and coherence in the 10-25 Hz frequency band on the affected side in hemiplegic patients during walking. SIGNIFICANCE: This is of importance for understanding the mechanisms responsible for reduced gait ability and development of new strategies for gait restoration.

U2 - 10.1016/j.clinph.2008.07.283

DO - 10.1016/j.clinph.2008.07.283

M3 - Journal article

C2 - 18848803

SN - 1388-2457

VL - 119

SP - 2813

EP - 2818

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 12

ER -