Redemitting BODIPY boronic acid fluorescent sensors for detection of lactate

TY - JOUR

T1 - Redemitting BODIPY boronic acid fluorescent sensors for detection of lactate

AU - Hansen, Jon Stefan

AU - Hoeg-Jensen, Thomas

AU - Christensen, Jørn Bolstad

PY - 2017

Y1 - 2017

N2 - Two redemitting BODIPY boronic acid pinacolate derivatives, sensors 1 and 2 were shown to act as excellent and highly selective lactate detectors at physiological pH (7.4), where the formed sensor-lactate complexes exhibited a significant emission and absorption increase. Since hyperlactataemia ([L-lac] > 6.5 mM) is a common complication in intensive care units, there is need for easy, on-line monitoring of lactate levels in patients. Semi-invasive monitoring via a lactate electrode or optic fiber would be attractive. This may beneficially replace existing lactate detection methods requiring a high degree of instrumentation. Sensors 1 and 2 can detect lactate without interference from biological important monosaccharides, such as D-glucose, D-fructose and D-mannose.

AB - Two redemitting BODIPY boronic acid pinacolate derivatives, sensors 1 and 2 were shown to act as excellent and highly selective lactate detectors at physiological pH (7.4), where the formed sensor-lactate complexes exhibited a significant emission and absorption increase. Since hyperlactataemia ([L-lac] > 6.5 mM) is a common complication in intensive care units, there is need for easy, on-line monitoring of lactate levels in patients. Semi-invasive monitoring via a lactate electrode or optic fiber would be attractive. This may beneficially replace existing lactate detection methods requiring a high degree of instrumentation. Sensors 1 and 2 can detect lactate without interference from biological important monosaccharides, such as D-glucose, D-fructose and D-mannose.

U2 - 10.1016/j.tet.2017.04.019

DO - 10.1016/j.tet.2017.04.019

M3 - Journal article

SN - 0040-4020

VL - 73

SP - 3010

EP - 3013

JO - Tetrahedron

JF - Tetrahedron

IS - 21

ER -