TY - JOUR
T1 - Recommendations on reintroduction of agalsidase Beta for patients with fabry disease in europe, following a period of shortage
AU - Linthorst, Gabor E
AU - Burlina, Alessandro P
AU - Cecchi, Franco
AU - Cox, Timothy M
AU - Fletcher, Janice M
AU - Feldt-Rasmussen, Ulla
AU - Giugliani, Roberto
AU - Hollak, Carla E M
AU - Houge, Gunnar
AU - Hughes, Derralynn
AU - Kantola, Iikka
AU - Lachmann, Robin
AU - Lopez, Monica
AU - Ortiz, Alberto
AU - Parini, Rossella
AU - Rivera, Alberto
AU - Rolfs, Arndt
AU - Ramaswami, Uma
AU - Svarstad, Einar
AU - Tondel, Camilla
AU - Tylki-Szymanska, Anna
AU - Vujkovac, Bojan
AU - Waldek, Steven
AU - West, Michael
AU - Weidemann, F
AU - Mehta, Atul
PY - 2013
Y1 - 2013
N2 - The interruption of the manufacturing process of agalsidase beta has led to a worldwide shortage of this drug. In the EU, nearly all patients initially reduced their agalsidase beta dose, and many of these switched to agalsidase alfa (Replagal Shire HGT). The clinical consequences of this period of drug shortage need to be further evaluated. A gradual increase of agalsidase beta supply is now expected. This implies that patients could resume or even commence agalsidase beta treatment. Guidance for prioritization of patients is needed to support equitable distribution of agalsidase beta to EU member states. To achieve this, in absence of level I clinical evidence, a draft consensus proposal was initiated and distributed. No full consensus was achieved, as there is disagreement regarding the indications for switching patients from agalsidase alfa to agalsidase beta. Some physicians support the concept that the 1.0 mg/kg EOW dose of agalsidase beta is more effective than agalsidase alfa at 0.2 mg/kg EOW, while others believe that at recommended dose, the preparations are equivalent. In light of these difficulties and the uncertainties with respect to supply of agalsidase beta, recommendations were agreed upon by a subgroup of physicians. These current recommendations focus on prioritization of criteria indicative of disease progression.
AB - The interruption of the manufacturing process of agalsidase beta has led to a worldwide shortage of this drug. In the EU, nearly all patients initially reduced their agalsidase beta dose, and many of these switched to agalsidase alfa (Replagal Shire HGT). The clinical consequences of this period of drug shortage need to be further evaluated. A gradual increase of agalsidase beta supply is now expected. This implies that patients could resume or even commence agalsidase beta treatment. Guidance for prioritization of patients is needed to support equitable distribution of agalsidase beta to EU member states. To achieve this, in absence of level I clinical evidence, a draft consensus proposal was initiated and distributed. No full consensus was achieved, as there is disagreement regarding the indications for switching patients from agalsidase alfa to agalsidase beta. Some physicians support the concept that the 1.0 mg/kg EOW dose of agalsidase beta is more effective than agalsidase alfa at 0.2 mg/kg EOW, while others believe that at recommended dose, the preparations are equivalent. In light of these difficulties and the uncertainties with respect to supply of agalsidase beta, recommendations were agreed upon by a subgroup of physicians. These current recommendations focus on prioritization of criteria indicative of disease progression.
U2 - 10.1007/8904_2012_160
DO - 10.1007/8904_2012_160
M3 - Journal article
C2 - 23430520
SN - 2192-8304
VL - 8
SP - 51
EP - 56
JO - JIMD Reports
JF - JIMD Reports
ER -