Recent advances in understanding and managing contact dermatitis: 3 approved]

TY - JOUR

T1 - Recent advances in understanding and managing contact dermatitis

T2 - 3 approved]

AU - Martin, Stefan F.

AU - Rustemeyer, Thomas

AU - Thyssen, Jacob P.

PY - 2018

Y1 - 2018

N2 - About 20% of the general population is contact-sensitized to common haptens such as fragrances, preservatives, and metals. Many also develop allergic contact dermatitis (ACD), the clinical manifestation of contact sensitization. ACD represents a common health issue and is also one of the most important occupational diseases. Although this inflammatory skin disease is mediated predominantly by memory T lymphocytes recognizing low-molecular-weight chemicals after skin contact, the innate immune system also plays an important role. Along that line, the presence of irritants may increase the risk of ACD and therefore ACD is often seen in the context of irritant contact dermatitis. In this review article, we discuss recent progress in basic research that has dramatically increased our understanding of the pathomechanisms of ACD and provides a basis for the development of novel diagnostic and therapeutic measures. Current methods for diagnosis as well as treatment options of ACD are also discussed.

AB - About 20% of the general population is contact-sensitized to common haptens such as fragrances, preservatives, and metals. Many also develop allergic contact dermatitis (ACD), the clinical manifestation of contact sensitization. ACD represents a common health issue and is also one of the most important occupational diseases. Although this inflammatory skin disease is mediated predominantly by memory T lymphocytes recognizing low-molecular-weight chemicals after skin contact, the innate immune system also plays an important role. Along that line, the presence of irritants may increase the risk of ACD and therefore ACD is often seen in the context of irritant contact dermatitis. In this review article, we discuss recent progress in basic research that has dramatically increased our understanding of the pathomechanisms of ACD and provides a basis for the development of novel diagnostic and therapeutic measures. Current methods for diagnosis as well as treatment options of ACD are also discussed.

KW - Chemical

KW - Contact dermatitis

KW - Skin

KW - Treatment

U2 - 10.12688/f1000research.13499.1

DO - 10.12688/f1000research.13499.1

M3 - Review

C2 - 29983912

AN - SCOPUS:85049121917

SN - 2046-1402

VL - 7

JO - F1000Research

JF - F1000Research

M1 - 810

ER -