TY - JOUR
T1 - RecA-DNA filament topology: the overlooked alternative of an unconventional syn-syn duplex intermediate
AU - Egel, Richard
N1 - Keywords: Animals; Base Pairing; DNA; Humans; Nucleic Acid Conformation; Rec A Recombinases; Recombination, Genetic
PY - 2007
Y1 - 2007
N2 - The helical filaments of RecA protein mediate strand exchange for homologous recombination, but the paths of the interacting DNAs have yet to be determined. Although this interaction is commonly limited to three strands, it is reasoned here that the intrinsic symmetry relationships of quadruplex topology are superior in explaining a range of observations. In particular, this topology suggests the potential of post-exchange base pairing in the unorthodox configuration of syn-syn glycosidic bonds between the nucleotide bases and the pentose rings in the sugar-phosphate backbone, which would transiently be stabilized by the external scaffolding of the RecA protein filament.
AB - The helical filaments of RecA protein mediate strand exchange for homologous recombination, but the paths of the interacting DNAs have yet to be determined. Although this interaction is commonly limited to three strands, it is reasoned here that the intrinsic symmetry relationships of quadruplex topology are superior in explaining a range of observations. In particular, this topology suggests the potential of post-exchange base pairing in the unorthodox configuration of syn-syn glycosidic bonds between the nucleotide bases and the pentose rings in the sugar-phosphate backbone, which would transiently be stabilized by the external scaffolding of the RecA protein filament.
U2 - 10.1016/j.dnarep.2006.12.013
DO - 10.1016/j.dnarep.2006.12.013
M3 - Journal article
C2 - 17317338
SN - 1568-7864
VL - 6
SP - 669
EP - 675
JO - DNA Repair
JF - DNA Repair
IS - 5
ER -