Rationale, design, and method of the Diabetes & Women's Health study – a study of long-term health implications of glucose intolerance in pregnancy and their determinants

TY - JOUR

T1 - Rationale, design, and method of the Diabetes & Women's Health study – a study of long-term health implications of glucose intolerance in pregnancy and their determinants

AU - Zhang, Cuilin

AU - Hu, Frank B

AU - Olsen, Sjurdur F

AU - Vaag, Allan

AU - Gore-Langton, Robert

AU - Chavarro, Jorge E

AU - Bao, Wei

AU - Yeung, Edwina

AU - Bowers, Katherine

AU - Grunnet, Louise G

AU - Sherman, Seth

AU - Kiely, Michele

AU - Strøm, Marin

AU - Hansen, Susanne

AU - Liu, Aiyi

AU - Mills, James

AU - Fan, Ruzong

AU - DWH study team

N1 - © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 diabetes and comorbidities after pregnancy. Little is known about the role of genetic factors and their interactions with environmental factors in determining the transition from gestational diabetes mellitus to overt type 2 diabetes mellitus. These critical data gaps served as the impetus for this Diabetes & Women's Health study with the overall goal of investigating genetic factors and their interactions with risk factors amenable to clinical or public health interventions in relation to the transition of gestational diabetes mellitus to type 2 diabetes mellitus. To achieve the goal efficiently, we are applying a hybrid design enrolling and collecting data longitudinally from approximately 4000 women with a medical history of gestational diabetes mellitus in two existing prospective cohorts, the Nurses' Health Study II and the Danish National Birth Cohort. Women who had a medical history of gestational diabetes mellitus in one or more of their pregnancies are eligible for the present study. After enrollment, we follow study participants for an additional 2 years to collect updated information on major clinical and environmental factors that may predict type 2 diabetes mellitus risk as well as with biospecimens to measure genetic and biochemical markers implicated in glucose metabolism. Newly collected data will be appended to the relevant existing data for the creation of a new database inclusive of genetic, epigenetic and environmental data. Findings from the study are critical for the development of targeted and more effective strategies to prevent type 2 diabetes mellitus and its complications in this high-risk population.

AB - Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 diabetes and comorbidities after pregnancy. Little is known about the role of genetic factors and their interactions with environmental factors in determining the transition from gestational diabetes mellitus to overt type 2 diabetes mellitus. These critical data gaps served as the impetus for this Diabetes & Women's Health study with the overall goal of investigating genetic factors and their interactions with risk factors amenable to clinical or public health interventions in relation to the transition of gestational diabetes mellitus to type 2 diabetes mellitus. To achieve the goal efficiently, we are applying a hybrid design enrolling and collecting data longitudinally from approximately 4000 women with a medical history of gestational diabetes mellitus in two existing prospective cohorts, the Nurses' Health Study II and the Danish National Birth Cohort. Women who had a medical history of gestational diabetes mellitus in one or more of their pregnancies are eligible for the present study. After enrollment, we follow study participants for an additional 2 years to collect updated information on major clinical and environmental factors that may predict type 2 diabetes mellitus risk as well as with biospecimens to measure genetic and biochemical markers implicated in glucose metabolism. Newly collected data will be appended to the relevant existing data for the creation of a new database inclusive of genetic, epigenetic and environmental data. Findings from the study are critical for the development of targeted and more effective strategies to prevent type 2 diabetes mellitus and its complications in this high-risk population.

KW - Adult

KW - Diabetes Mellitus, Type 2

KW - Diabetes, Gestational

KW - Female

KW - Gene-Environment Interaction

KW - Genetic Predisposition to Disease

KW - Glucose Intolerance

KW - Glucose Tolerance Test

KW - Humans

KW - Nurses

KW - Pregnancy

KW - Pregnancy Complications

KW - Prospective Studies

KW - Questionnaires

KW - Research Design

KW - Risk Factors

KW - United States

U2 - 10.1111/aogs.12425

DO - 10.1111/aogs.12425

M3 - Journal article

C2 - 24828694

SN - 0001-6349

VL - 93

SP - 1123

EP - 1130

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 11

ER -