Rare childhood hybrid histiocytosis of the central nervous system-diagnosed by stereotactic brain biopsy with marked treatment response to clofarabine

J Foss-Skiftesvik; D Scheie; C Klausen; A Sehested; J Skjøth-Rasmussen

doi:10.1007/s00381-018-3859-x

Rare childhood hybrid histiocytosis of the central nervous system-diagnosed by stereotactic brain biopsy with marked treatment response to clofarabine

J Foss-Skiftesvik, D Scheie, C Klausen, A Sehested, J Skjøth-Rasmussen

Institut for Klinisk Medicin

2 Citationer (Scopus)

Abstract

Histiocytosis is a heterogeneous group of disease entities, comprised by two main categories, namely Langerhans and non-Langerhans cell histiocytoses. Central nervous system involvement in histiocytosis is considered very rare and is often secondary to affection of anatomically related bone structures and/or multi-organ disease. We present a never-before described case of rare childhood histiocytosis with hybrid features of Langerhans cell histiocytosis and juvenile xanthogranuloma confined to the central nervous system in a 2- and a half-year-old boy with distinct treatment response to clofarabine. The case also emphasizes the diagnostic significance of stereotactic brain biopsy.

Originalsprog	Engelsk
Tidsskrift	Child's Nervous System
Vol/bind	34
Udgave nummer	11
Sider (fra-til)	2321-2324
Antal sider	4
ISSN	0256-7040
DOI	https://doi.org/10.1007/s00381-018-3859-x
Status	Udgivet - 1 nov. 2018

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10.1007/s00381-018-3859-x

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title = "Rare childhood hybrid histiocytosis of the central nervous system-diagnosed by stereotactic brain biopsy with marked treatment response to clofarabine",

abstract = "Histiocytosis is a heterogeneous group of disease entities, comprised by two main categories, namely Langerhans and non-Langerhans cell histiocytoses. Central nervous system involvement in histiocytosis is considered very rare and is often secondary to affection of anatomically related bone structures and/or multi-organ disease. We present a never-before described case of rare childhood histiocytosis with hybrid features of Langerhans cell histiocytosis and juvenile xanthogranuloma confined to the central nervous system in a 2- and a half-year-old boy with distinct treatment response to clofarabine. The case also emphasizes the diagnostic significance of stereotactic brain biopsy.",

author = "J Foss-Skiftesvik and D Scheie and C Klausen and A Sehested and J Skj{\o}th-Rasmussen",

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T1 - Rare childhood hybrid histiocytosis of the central nervous system-diagnosed by stereotactic brain biopsy with marked treatment response to clofarabine

AU - Foss-Skiftesvik, J

AU - Scheie, D

AU - Klausen, C

AU - Sehested, A

AU - Skjøth-Rasmussen, J

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Histiocytosis is a heterogeneous group of disease entities, comprised by two main categories, namely Langerhans and non-Langerhans cell histiocytoses. Central nervous system involvement in histiocytosis is considered very rare and is often secondary to affection of anatomically related bone structures and/or multi-organ disease. We present a never-before described case of rare childhood histiocytosis with hybrid features of Langerhans cell histiocytosis and juvenile xanthogranuloma confined to the central nervous system in a 2- and a half-year-old boy with distinct treatment response to clofarabine. The case also emphasizes the diagnostic significance of stereotactic brain biopsy.

AB - Histiocytosis is a heterogeneous group of disease entities, comprised by two main categories, namely Langerhans and non-Langerhans cell histiocytoses. Central nervous system involvement in histiocytosis is considered very rare and is often secondary to affection of anatomically related bone structures and/or multi-organ disease. We present a never-before described case of rare childhood histiocytosis with hybrid features of Langerhans cell histiocytosis and juvenile xanthogranuloma confined to the central nervous system in a 2- and a half-year-old boy with distinct treatment response to clofarabine. The case also emphasizes the diagnostic significance of stereotactic brain biopsy.

U2 - 10.1007/s00381-018-3859-x

DO - 10.1007/s00381-018-3859-x

M3 - Journal article

C2 - 29872899

SN - 0256-7040

VL - 34

SP - 2321

EP - 2324

JO - Child's Nervous System

JF - Child's Nervous System

IS - 11

ER -

Rare childhood hybrid histiocytosis of the central nervous system-diagnosed by stereotactic brain biopsy with marked treatment response to clofarabine

Abstract

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