TY - JOUR
T1 - Rapid formation of a preoligomeric peptide-metal-peptide complex following copper(II) binding to amyloid β peptides
AU - Pedersen, Jeppe Trudslev
AU - Teilum, Kaare
AU - Heegaard, Niels H. H.
AU - Østergaard, Jesper
AU - Adolph, Hans-Werner
AU - Hemmingsen, Lars Bo Stegeager
PY - 2011/3/7
Y1 - 2011/3/7
N2 - Cu II connects peptides: The mechanism of binding of Cu II to amyloid β peptides (Aβ) implicated in Alzheimer's disease was elucidated by stopped-flow spectroscopy, NMR relaxation, and simulation of the kinetics on the millisecond timescale. Two monomeric Cu-Aβ species and a dimeric Aβ-Cu-Aβ species were identified (see picture). Aberrant aggregation apparently occurs from the monomeric species.
AB - Cu II connects peptides: The mechanism of binding of Cu II to amyloid β peptides (Aβ) implicated in Alzheimer's disease was elucidated by stopped-flow spectroscopy, NMR relaxation, and simulation of the kinetics on the millisecond timescale. Two monomeric Cu-Aβ species and a dimeric Aβ-Cu-Aβ species were identified (see picture). Aberrant aggregation apparently occurs from the monomeric species.
KW - Former Faculty of Pharmaceutical Sciences
KW - Former LIFE faculty
U2 - 10.1002/anie.201006335
DO - 10.1002/anie.201006335
M3 - Letter
C2 - 21370331
SN - 1433-7851
VL - 50
SP - 2532
EP - 2535
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
IS - 11
ER -