Raman spectroscopy in pharmaceutical product design

Amrit Paudel; Dhara Raijada; Jukka Rantanen

doi:10.1016/j.addr.2015.04.003

Raman spectroscopy in pharmaceutical product design

Amrit Paudel, Dhara Raijada, Jukka Rantanen

148 Citationer (Scopus)

Abstract

Almost 100 years after the discovery of the Raman scattering phenomenon, related analytical techniques have emerged as important tools in biomedical sciences. Raman spectroscopy and microscopy are frontier, non-invasive analytical techniques amenable for diverse biomedical areas, ranging from molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed.

Originalsprog	Engelsk
Tidsskrift	Advanced Drug Delivery Reviews
Vol/bind	89
Sider (fra-til)	3-20
Antal sider	18
ISSN	0169-409X
DOI	https://doi.org/10.1016/j.addr.2015.04.003
Status	Udgivet - 15 jul. 2015

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10.1016/j.addr.2015.04.003

Citationsformater

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title = "Raman spectroscopy in pharmaceutical product design",

abstract = "Almost 100 years after the discovery of the Raman scattering phenomenon, related analytical techniques have emerged as important tools in biomedical sciences. Raman spectroscopy and microscopy are frontier, non-invasive analytical techniques amenable for diverse biomedical areas, ranging from molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed.",

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author = "Amrit Paudel and Dhara Raijada and Jukka Rantanen",

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doi = "10.1016/j.addr.2015.04.003",

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T1 - Raman spectroscopy in pharmaceutical product design

AU - Paudel, Amrit

AU - Raijada, Dhara

AU - Rantanen, Jukka

PY - 2015/7/15

Y1 - 2015/7/15

N2 - Almost 100 years after the discovery of the Raman scattering phenomenon, related analytical techniques have emerged as important tools in biomedical sciences. Raman spectroscopy and microscopy are frontier, non-invasive analytical techniques amenable for diverse biomedical areas, ranging from molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed.

AB - Almost 100 years after the discovery of the Raman scattering phenomenon, related analytical techniques have emerged as important tools in biomedical sciences. Raman spectroscopy and microscopy are frontier, non-invasive analytical techniques amenable for diverse biomedical areas, ranging from molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed.

KW - Chemistry, Pharmaceutical

KW - Drug Delivery Systems

KW - Drug Design

KW - Drug Discovery

KW - Humans

KW - Pharmaceutical Preparations

KW - Quality Control

KW - Spectrum Analysis, Raman

KW - Technology, Pharmaceutical

U2 - 10.1016/j.addr.2015.04.003

DO - 10.1016/j.addr.2015.04.003

M3 - Journal article

C2 - 25868453

SN - 0169-409X

VL - 89

SP - 3

EP - 20

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Raman spectroscopy in pharmaceutical product design

Abstract

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