Radium-223 behandling af knoglemetastaser ved kastrationsrefraktær prostatacancer

Jann Mortensen; Liselotte Højgaard

Radium-223 behandling af knoglemetastaser ved kastrationsrefraktær prostatacancer

Institut for Klinisk Medicin

Abstract

The alpha emitter Radium-223 ((22)3Ra-Cl2) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone refractory prostate cancer. More than 1,000 patients have been included in clinical phase I-III tests showing significant reduction in alkaline phosphatase- and PSA level and prolonged survival. Adverse events are usually mild to moderate and comprise gastrointestinal and myelotoxic symp-toms. Intravenously administered (22)3Ra-Cl2 (half-life 11.4 days) will likely be given every four weeks for six treatments to out-patients.

Bidragets oversatte titel	Radium-223 treatment of bone metastases from castration-resistant prostate cancer.
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	176
Udgave nummer	30
Sider (fra-til)	1399-1402
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 21 jul. 2014

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Citationsformater

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AU - Mortensen, Jann

AU - Højgaard, Liselotte

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N2 - The alpha emitter Radium-223 ((22)3Ra-Cl2) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone refractory prostate cancer. More than 1,000 patients have been included in clinical phase I-III tests showing significant reduction in alkaline phosphatase- and PSA level and prolonged survival. Adverse events are usually mild to moderate and comprise gastrointestinal and myelotoxic symp-toms. Intravenously administered (22)3Ra-Cl2 (half-life 11.4 days) will likely be given every four weeks for six treatments to out-patients.

AB - The alpha emitter Radium-223 ((22)3Ra-Cl2) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone refractory prostate cancer. More than 1,000 patients have been included in clinical phase I-III tests showing significant reduction in alkaline phosphatase- and PSA level and prolonged survival. Adverse events are usually mild to moderate and comprise gastrointestinal and myelotoxic symp-toms. Intravenously administered (22)3Ra-Cl2 (half-life 11.4 days) will likely be given every four weeks for six treatments to out-patients.

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SN - 0041-5782

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JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

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Radium-223 behandling af knoglemetastaser ved kastrationsrefraktær prostatacancer

Abstract

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