Radicals derived from histone hydroperoxides damage nucleobases in RNA and DNA

Medicin og biovidenskab

• 8-Hydroxy-2'-Deoxyguanosine 13%
• calf thymus DNA 15%
• Deoxyguanosine 14%
• DNA 51%
• High Pressure Liquid Chromatography 8%
• Histones 86%
• Hot Temperature 7%
• Hydrogen Peroxide 92%
• Hydroxyl Radical 11%
• Ions 16%
• Light Metals 19%
• Metals 17%
• Proteins 22%
• purine 11%
• pyrimidine 25%
• RNA 63%
• Spectrum Analysis 10%
• Spin Trapping 15%
• Uridine 12%

Kemiske forbindelser

• Adduct 7%
• Catalyst 4%
• Decomposition 13%
• Double Bond 7%
• EPR Spectroscopy 8%
• Gamma-Irradiation 11%
• Heat 7%
• Histone 98%
• Hydroperoxide 94%
• Metal 4%
• Metal Ion 12%
• Molecule 3%
• Nucleobase 100%
• Protein 21%
• Purine Nucleobase 16%
• Pyrimidine 9%
• Pyrimidine Nucleobase 16%
• Reaction Yield 4%
• Spin Trapping 12%
• Transition Element 7%
• Uridine 11%