Quantitative Real-Time PCR in aDNA Research

Mike Bunce, Charlotte Oskam, Morten Erik Allentoft

20 Citationer (Scopus)

Abstract

Quantitative real-time PCR (qPCR) is a technique that is widely used in the field of ancient DNA (aDNA). Quantitative PCR can be used to optimize aDNA extraction methodologies, to detect PCR inhibition, and to quantify aDNA libraries for use in high-throughput sequencing. In this chapter, we outline factors that need to be considered when developing efficient SYBR Green qPCR assays. We describe how to setup qPCR standards of known copy number and provide some useful tips regarding interpretation of qPCR data generated from aDNA templates.

OriginalsprogEngelsk
TitelAncient DNA: Methods and Protocols
RedaktørerBeth Shapiro, Michael Hofreiter
Antal sider12
ForlagSpringer Science+Business Media
Publikationsdato2012
Sider121-132
Kapitel16
ISBN (Trykt)978-1-61779-515-2
DOI
StatusUdgivet - 2012
Udgivet eksterntJa
NavnMethods in Molecular Biology
Vol/bind840

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